Multi-Site Studies for System-Level Implementation of Substance Use Prevention and Treatment Services (R01)

PAR-16-455
Multi-Site Studies for System-Level Implementation of Substance Use Prevention and Treatment Services (R01)
Department of Health and Human Services
National Institutes of Health

Section I. Funding Opportunity DescriptionRx-Drugs

Implementation science is a growing field. An early area of emphasis for addiction health services researchers was to move beyond training of individual clinicians or service providers as a default implementation strategy, and develop interventions that would achieve broader, sustainable implementation at the organizational level. Some research has begun to look at intra-organizational implementation strategies to further accelerate the implementation of evidence-based practices (or de-implementation of unsupported or harmful practices). However, to date, a major remaining challenge is how to facilitate – in a systematic, scalable, sustainable way – the delivery of evidence-based prevention and treatment services at a system level.

This FOA seeks research projects that will move beyond a focus on how individual clinics or organizations implement a given change, and beyond implementation of interventions that target only a single evidence-based intervention (EBI). The purpose of this FOA is to identify efficacious and effective strategies or techniques for facilitating systems-level change within or across networks of organizations to promote broad use of evidence-based practices for the prevention and/or treatment of substance use disorders or HIV. This FOA seeks applications that can address implementation on a larger, system-level scale that is more analogous to the way policy changes lead to system-level changes in prevention and treatment service delivery. Achieving system-level improvements requires implementation strategies that are sufficiently flexible to address the variation in settings and context across a given system, but that are also generalizable across settings. The multi-site studies supported by this FOA should contribute both practical and conceptual advances.  In practical terms, these studies should provide strategies that can be used to effectively deploy guidelines, practices, and policies across entire systems of care.  In conceptual terms, these studies should also leverage the multi-site platform to test implementation science hypotheses, explore novel methodological approaches, or test new measures or models that can inform future implementation research in this or other health domains.

General Information

Document Type: Grants Notice
Funding Opportunity Number: PAR-16-455
Funding Opportunity Title: Multi-Site Studies for System-Level Implementation of Substance Use Prevention and Treatment Services (R01)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Grant
Category of Funding Activity: Education
Health
Category Explanation:  
Expected Number of Awards:  
CFDA Number(s): 93.273 — Alcohol Research Programs
93.279 — Drug Abuse and Addiction Research Programs
93.399 — Cancer Control
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Sep 30, 2016
Last Updated Date: Sep 30, 2016
Original Closing Date for Applications: Nov 13, 2020  
Current Closing Date for Applications: Nov 13, 2020  
Archive Date: Dec 14, 2020
Estimated Total Program Funding:  
Award Ceiling: $500,000
Award Floor:

Eligibility

Eligible Applicants: Public housing authorities/Indian housing authorities
City or township governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
State governments
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Independent school districts
Public and State controlled institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
For profit organizations other than small businesses
County governments
Private institutions of higher education
Native American tribal governments (Federally recognized)
Special district governments
Small businesses
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Additional Information

Agency Name: National Institutes of Health
Description: As part of the Collaborative Research on Addiction at NIH (CRAN) initiative, NIDA, NIAAA, and NCI join to issue this FOA. The purpose of this FOA is to support the development and testing of interventions, models, and/or frameworks that examine system-level implementation of evidence-based interventions, guidelines, or principles to improve the delivery, uptake, quality, and sustainability of substance use prevention and treatment interventions and services.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PAR-16-455.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

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BRAIN Initiative: Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain (R01)

RFA-MH-17-220
BRAIN Initiative: Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain (R01)
Department of Health and Human Services
National Institutes of Health

neuron

Research Objectives

This funding opportunity announcement (FOA) is designed to support development and validation of novel tools to facilitate the detailed analysis of cells and circuits and provide insights into the neural circuitry and structure underlying complex behaviors. The human brain consists of an estimated one hundred billion neurons and more than one trillion supporting glial cells that are uniquely organized to confer the extraordinary computational activities of the brain. Cell types are categorized by their anatomical position, neurotransmitter content, dendritic and axonal connections, receptor profile, gene expression profile and distinct electrical properties. Although the human brain has long been the focus of numerous studies with many major achievements along the way, to date we remain largely ignorant about the specific details such as cell types and connections that are responsible for rapid information processing. Defining cellular and circuit-level function is dependent on detailed knowledge about the components and structure of the circuit. Such knowledge, in turn, is fundamental to understanding how these features underlie cognition and behavior, which should aid in the development of targeted cell-type and circuit-specific therapeutics to treat brain disorders. This initiative is focused on developing tools (or vastly improving existing tools) to enable access to individual cells and defined groups of cells within neuronal circuits. The tools sought through this FOA can include novel genetic or non-genetic methods for targeted delivery of genes, proteins, and chemicals to specific cells or tightly defined cell types and circuits.

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-MH-17-220
Funding Opportunity Title: BRAIN Initiative: Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain (R01)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Grant
Category of Funding Activity: Education
Health
Income Security and Social Services
Category Explanation:  
Expected Number of Awards:  
CFDA Number(s): 93.173 — Research Related to Deafness and Communication Disorders
93.213 — Research and Training in Complementary and Integrative Health
93.242 — Mental Health Research Grants
93.273 — Alcohol Research Programs
93.279 — Drug Abuse and Addiction Research Programs
93.286 — Discovery and Applied Research for Technological Innovations to Improve Human Health
93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders
93.865 — Child Health and Human Development Extramural Research
93.866 — Aging Research
93.867 — Vision Research
Cost Sharing or Matching Requirement: No
Version: Synopsis 2
Posted Date: Aug 10, 2016
Last Updated Date: Sep 16, 2016
Original Closing Date for Applications: Nov 02, 2016  
Current Closing Date for Applications: Oct 13, 2017  
Archive Date: Nov 12, 2017
Estimated Total Program Funding:  
Award Ceiling:  
Award Floor:  

Eligibility

Eligible Applicants: Private institutions of higher education
State governments
Special district governments
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
County governments
Small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
Independent school districts
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Others (see text field entitled “Additional Information on Eligibility” for clarification)
City or township governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
For profit organizations other than small businesses
Public housing authorities/Indian housing authorities
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Tools that can be used in a number of species/model organisms rather than those restricted to a single species are highly desired. Applications that provide approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged.
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-17-220.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

NIAID Career Transition Award (K22)

PAR-14-341
NIAID Career Transition Award (K22)
Department of Health and Human Servicesmulti-ethnic-scientists-in-lab-article
National Institutes of Health

Section I. Funding Opportunity Description

The overall goal of the NIH Research Career Development program is to help ensure that a diverse pool of highly trained scientists is available in appropriate scientific disciplines to address the Nation’s biomedical, behavioral, and clinical research needs. In addition to this opportunity, NIH Institutes and Centers (ICs) support a variety of other mentored career development programs designed to foster the transition of new investigators to research independence. These other programs may be more suitable for particular candidates.  NIH also supports non-mentored career development programs for independent investigators. More information about Career programs may be found at the NIH Extramural Training Mechanisms website.

The objective of the of the NIAID Career Transition Award is to support postdoctoral fellows transitioning to positions of assistant professor or equivalent, and initiate a successful biomedical career as an independent research scientist.

NIH believes that the creativity and innovation of new independent investigators in their early career stages play an integral role in addressing our Nation’s biomedical, behavioral, and clinical research needs. However, the average age of first-time (new) Principal Investigators obtaining R01 research funding from the NIH has risen to 42 years for Ph.D. degree holders and 44 years for M.D./Ph.D. degree holders in 2013. The intent of the NIAID K22 program is to help alleviate this trend and to assist new investigators in transitioning to stable independent research positions at an earlier age and with an enhanced probability of success in obtaining independent NIH or other independent research support.

Nature of the career/research transition opportunity

The K22 award will provide two years of support to conduct biomedical research as an independent scientist at an extramural sponsoring institution/organization to which the individual has been recruited, been offered and has accepted a tenure-track full-time assistant professor position (or equivalent). This support is to allow the individual to continue to work toward establishing his/her own independent research program and prepare an application for regular research grant support (R01).

The postdoctoral fellow, also referred to as a candidate, submits a K22 application from the institution where s/he currently pursues his/her postdoctoral research training.  The application will be peer reviewed and assigned an overall impact score.  Successful candidates (i.e. whose application has received a fundable overall impact score) will receive an approval letter from NIAID that will include the terms and conditions to activate the K22 award. In order to activate the K22 award, the candidate will need to secure a tenure-track full-time assistant professor position within a year of the receipt of the approval letter.  Once the assistant professor position has been secured, the candidate will submit updated information about the K22 application with the support of the sponsoring institution.  The sponsoring institution can be the same as the post-doctoral institution, though it is most likely a different institution from the original submission of the K22 application.  The updated information of the transition to an assistant professor position at the sponsoring institution will be evaluated by senior NIAID staff to ensure that all programmatic requirements are met prior to the activation of the K22 award. The details of the requirements for the activation of the K22 award are described in Section VI of this announcement.

General Information

Document Type: Grants Notice
Funding Opportunity Number: PAR-14-341
Funding Opportunity Title: NIAID Career Transition Award (K22)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Grant
Category of Funding Activity: Health
Category Explanation:  
Expected Number of Awards:  
CFDA Number(s): 93.855 — Allergy, Immunology and Transplantation Research
93.856 — Microbiology and Infectious Diseases Research
Cost Sharing or Matching Requirement: No
Version: Synopsis 2
Posted Date: Sep 12, 2014
Last Updated Date: Sep 16, 2016
Original Closing Date for Applications: Sep 07, 2017  
Current Closing Date for Applications: Sep 16, 2016  
Archive Date: Oct 16, 2016
Estimated Total Program Funding:  
Award Ceiling:  
Award Floor:  

Eligibility

Eligible Applicants: Small businesses
Special district governments
County governments
City or township governments
Native American tribal governments (Federally recognized)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Independent school districts
Public housing authorities/Indian housing authorities
For profit organizations other than small businesses
Public and State controlled institutions of higher education
Private institutions of higher education
State governments
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Native American tribal organizations (other than Federally recognized tribal governments)
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name: National Institutes of Health
Description: The purpose of the NIAID Career Transition Award (CTA) program is to increase and maintain a strong cohort of new and talented NIH-supported independent investigators that will address the health needs of the Nation. The NIAID CTA is specifically designed to facilitate the transition from a postdoctoral research position to an independent research position.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PAR-14-341.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

Identification of Mechanisms Mediating the Effects of Sleep on Diabetes-Related Metabolism in Humans (R01)

RFA-DK-16-005
Identification of Mechanisms Mediating the Effects of Sleep on Diabetes-Related Metabolism in Humans (R01)
Department of Health and Human Services
National Institutes of Health

Section I. Funding Opportunity Description

The purpose of this FOA is to invite applications that investigate the mechanisms mediating the interactions between sleep and diabetes-related metabolism using deep metabolic phenotyping approaches in healthy human populations and those with metabolic and/or sleep disorders.diabetes

Large, epidemiological studies support an association between disrupted sleep [sleep deprivation, sleep fragmentation, short sleep, and obstructive sleep apnea (OSA)] and dysregulated metabolism, specifically increased body weight and/or glucose intolerance. Small studies conducted primarily in healthy control subjects also indicate that laboratory-induced sleep deprivation impairs insulin sensitivity and may have effects on other metabolic indices that impact insulin sensitivity and glucose tolerance including circulating inflammatory markers, lipid metabolism, autonomic nervous system activity and food intake.  Small studies conducted in clinical populations such as individuals with OSA, also show a relationship between OSA and impaired glucose tolerance or decreased insulin sensitivity relative to matched controls. However, while small studies show treatment of OSA generally seems to improve insulin sensitivity, there are minimal effects on glucose tolerance.

The mechanisms mediating impairment of glucose metabolism and insulin sensitivity by sleep disruption are not known. Current animal models of sleep disruption often do not replicate the human sleep disorders and thus limit translation of findings from rodents into humans. To date, human studies examining the effects of sleep disruption on diabetes related metabolism have not included in-depth metabolic phenotyping that would contribute to elucidating potential mediators or to identifying the tissue site (or sites) associated with disrupted metabolism. Furthermore, the majority of studies on human sleep and glucose metabolism have been conducted in healthy subjects whose sleep has been disrupted by various interventions in a controlled laboratory setting. Few studies have attempted to treat sleep disorders in populations with metabolic or sleep disorders and demonstrate improvements in glucose homeostasis or diabetes-related metabolism. Identifying a population with a known metabolic or sleep disorder and being able to demonstrate that a therapeutic sleep intervention can ameliorate abnormalities in glucose or diabetes-related metabolism would have important clinical implications.

This FOA invites applications which propose in-depth metabolic phenotyping in carefully selected clinical populations to determine how changes in sleep (improvements or disruptions) influence diabetes-related metabolism. Applications should systematically test a physiological model with the goal of elucidating possible mediators of the reported effects of sleep on glucose metabolism. Applications that propose therapeutic interventions to improve sleep and determine the consequences on diabetes-related metabolism must have preliminary data demonstrating that the proposed method for improving sleep is actually efficacious.

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-DK-16-005
Funding Opportunity Title: Identification of Mechanisms Mediating the Effects of Sleep on Diabetes-Related Metabolism in Humans (R01)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Grant
Category of Funding Activity: Food and Nutrition
Health
Category Explanation:  
Expected Number of Awards:  
CFDA Number(s): 93.313 — NIH Office of Research on Women’s Health
93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Aug 17, 2016
Last Updated Date: Aug 17, 2016
Original Closing Date for Applications: Oct 11, 2017  
Current Closing Date for Applications: Oct 11, 2017  
Archive Date: Nov 11, 2017
Estimated Total Program Funding:  
Award Ceiling: $499,999
Award Floor:  

Eligibility

Eligible Applicants: Small businesses
Public and State controlled institutions of higher education
Public housing authorities/Indian housing authorities
State governments
City or township governments
For profit organizations other than small businesses
Independent school districts
Native American tribal governments (Federally recognized)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
Special district governments
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Native American tribal organizations (other than Federally recognized tribal governments)
County governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Additional Information

Agency Name: National Institutes of Health
Description: The purpose of this Funding Opportunity Announcement is to invite applications that investigate the mechanisms mediating the interactions between sleep and diabetes-related metabolism using deep metabolic phenotyping approaches in healthy human populations and those with metabolic and/or sleep disorders.
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-16-005.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

Nutrigenetics and Nutrigenomics Approaches for Nutrition Research (R01)

PA-16-332
Nutrigenetics and Nutrigenomics Approaches for Nutrition Research (R01)
Department of Health and Human Services
National Institutes of Health

neutrigenomics-10-728

The National Cancer Institute [NCI]

The National Cancer Institute has multiple interests in nutrigenetic and nutrigenomic-based mechanistic studies including vitamins, minerals and other nutritive agents present in food that reduce the risk of cancer.  Genetic variations present in individuals may alter their susceptibility to cancer. Specific interests include strategies to facilitate precision medicine using nutrition-focused interventions to reduce cancer risks in various populations including those mediated by host-microbiome interactions.

National Center for Complementary and Integrative Health [NCCIH]

The National Center for Complementary and Integrative Health (NCCIH) is particularly interested in nutrigenetic and nutigenomic-based mechanistic studies of interaction and competition between nutrient-nutrient, nutrient-drug, dietary supplements, and probiotics/prebiotics on host-microbial metabolism, immunologic/inflammatory signaling, neuro-hormonal pathways and target tissues [including bioavailability, absorption, transport, metabolism and excretion studies] that impact the basic fundamentals that will eventually lead to a better understanding of the gut brain function in health promotion and disease prevention. NCCIH is also interested in the impact of [selected] nutrient, dietary supplements, the ketogenic diet, and probiotic/prebiotic modulation of specific conditions including pain. In addition, NCCIH is interested in studying mechanisms for how botanical products, fish oil and other dietary supplements, and prebiotics in helping to identify their relationship to  pain and inflammation.

General Information

Document Type: Grants Notice
Funding Opportunity Number: PA-16-332
Funding Opportunity Title: Nutrigenetics and Nutrigenomics Approaches for Nutrition Research (R01)
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Grant
Category of Funding Activity: Education
Food and Nutrition
Health
Category Explanation:
Expected Number of Awards:
CFDA Number(s): 93.213 — Research and Training in Complementary and Integrative Health
93.321 — Dietary Supplement Research Program
93.393 — Cancer Cause and Prevention Research
93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research
Cost Sharing or Matching Requirement: No
Posted Date: Jun 15, 2016
Last Updated Date: Jun 15, 2016
Original Closing Date for Applications: Sep 07, 2019  
Current Closing Date for Applications: Sep 07, 2019  
Archive Date: Oct 08, 2019

Eligibility

Eligible Applicants:
Small businesses
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
City or township governments
Native American tribal governments (Federally recognized)
Special district governments
For profit organizations other than small businesses
State governments
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Independent school districts
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Public housing authorities/Indian housing authorities
Private institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Public and State controlled institutions of higher education
County governments
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name: National Institutes of Health
Description: The purpose of this Funding Opportunity Announcement (FOA) is to promote application of nutrigenetics and/or nutrigenomics approaches to nutrition research through collaborative interaction among nutrition researchers and experts in omics technologies.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PA-16-332.html
Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV
If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

Metabolic Contributions to the Neurocognitive Complications of Diabetes: Ancillary Studies (R01)

PAR-16-333
Metabolic Contributions to the Neurocognitive Complications of Diabetes: Ancillary Studies (R01)
Department of Health and Human Services
National Institutes of Health

cognitive-neuroscience-cognitive_neuroscience

Section I. Funding Opportunity Description

The purpose of this Funding Opportunity Announcement (FOA) is to elucidate the etiology and pathogenesis of the neurocognitive complications associated with type 2 diabetes (T2D) with the ultimate goal of informing future strategies to mitigate the risk of these complications. Applications should propose expansions of ongoing human studies of well characterized T2D cohorts or cohorts comparing T2D with non-diabetic populations.  Such expansions might include the addition of comprehensive neurocognitive measures (e.g., cognitive testing, neuroimaging, and biomarkers), clinical measures (e.g., insulin resistance, HbA1c), and/or collection of data on other risk factors (e.g., diet, obesity, micro- and macro-vascular disease, inflammation). It must be clearly explained how the collection of additional data will contribute to elucidation of the basis of neurocognitive sequelae of T2D.

Background: Emerging data have established links between T2D and neurocognitive impairment, including dementia. The current epidemic of dementia is driven, at least in part, by the concurrent epidemics of obesity, insulin resistance, T2D, and metabolic syndrome. Early research sought to elucidate the cause(s) for the apparent role of metabolic dysfunction in the increased prevalence of neurocognitive dysfunction and dementia, tentatively attributed to vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer’s disease (AD). Recent neuropathological research indicates that less than half of the variability in cognitive impairment in the years prior to death may be attributable to AD and other common pathologies, and it is unclear which pathologies are the primary drivers of the association between T2D and neurocognitive impairment and dementia.

Unlike other complications of T2D, neurocognitive complications of T2D have not clearly been demonstrated to correlate with measures of peripheral glycemia (with the exception of very poor glycemic control, HbA1c > 10%) and there is even less evidence for an association with other measures of peripheral glucose regulation (e.g., insulin concentration, insulin action, insulin resistance). The dearth of large-scale studies involving longitudinal assessment of T2D and associated risk factors for complications, neurocognition, and disease management has limited our knowledge of how specific parameters associated with T2D may lead to changes in brain structure and function and deficits in cognition, and how susceptibility to these brain changes may vary across the lifespan.  Moreover, it can be difficult to distinguish the etiology of cognitive impairment since individuals with T2D are at increased risk of other associated complications (e.g., obesity, micro- and macro-vascular disease) that can affect cognition. Recent advances in neuroimaging, computerized neurocognitive assessment, and the availability of large, well-characterized cohorts with T2D could lead to improvements in characterizing brain structure/function, cognition, and clinical parameters and other risk factors associated with T2D.  If specific parameters and other risk factors for adverse neurocognitive outcomes associated with T2D could be defined, treatment protocols could be developed to limit neurocognitive complications associated with T2D.

Types of ancillary studies might include, but are not limited to:

Addition of metabolic and clinical phenotyping in individuals with T2D (e.g., measurement of insulin resistance, HbA1c), including associated factors of relevance to neurocognitive complications of T2D (e.g., diet, obesity, micro- and macro-vascular disease, inflammation), to studies that are already obtaining detailed measurement of neurocognition.

Addition of cohorts with T2D and associated metabolic disease (insulin resistance, prediabetes) to studies that are already obtaining detailed measurement of neurocognition.

Addition of comprehensive neurocognitive measures (e.g., cognitive testing, neuroimaging, and fluid-based biomarkers) to existing studies of T2D cohorts with well-characterized clinical correlates and course of disease.

Regardless of the type of study design, there must be a plan to measure the variables of interest in the same cohort at a minimum of two well justified time points. Cross sectional and purely correlative research is not consistent with the goals of this initiative.

Research that can examine how genetic and environmental factors confer risk or protect against the neurocognitive complications of T2D is encouraged. Research that addresses how neurocognitive complications of T2D impact academic and occupational function (where relevant) and activities of daily living, including the relationship to management of disease and/or treatment adherence is also encouraged.

Research across the lifespan and healthspan is appropriate for this FOA; however, it is possible that due to aging and disease-related factors, isolating mechanisms may be more complex and clinical targets less modifiable as individuals advance in age and disease burden increases. Therefore, there will be a special emphasis on research earlier in the developmental spectrum, especially prior to the development of complex disease (e.g., severe complications of T2D, CVD, dementia).

Strong expertise in T2D and associated disease processes (obesity, insulin resistance, prediabetes) and neuroscience is important for the research teams that will carry out the research supported by this FOA. It is anticipated that many of the funded research studies will involve the analysis and interpretation of complex, high-dimensional datasets. Therefore, it is strongly encouraged to include data scientists with relevant expertise on the research team. Collaborations between basic and clinical scientists are also encouraged but not required.

This FOA is NOT intended to fund the following:

  • New clinical trials to test the efficacy of interventions for neurocognitive complications of T2D.
  • Animal studies.
  • Projects that need a new or separate clinical research infrastructure for sample collection and subject recruitment.  Projects that use samples or subjects from restricted clinical studies; such as those for which access to resources is only permitted to consortium members, or those that place restrictions on publications or data access that are inconsistent with NIH policy.
  • Core activities of ongoing clinical studies.

General Information

Document Type: Grants Notice
Funding Opportunity Number: PAR-16-333
Funding Opportunity Title: Metabolic Contributions to the Neurocognitive Complications of Diabetes: Ancillary Studies (R01)
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Grant
Category of Funding Activity: Food and Nutrition
Health
Category Explanation:
Expected Number of Awards:
CFDA Number(s): 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research
Cost Sharing or Matching Requirement: No
Posted Date: Jun 15, 2016
Last Updated Date: Jun 15, 2016
Original Closing Date for Applications: Sep 07, 2019  
Current Closing Date for Applications: Sep 07, 2019  
Archive Date: Oct 08, 2019

Eligibility

Eligible Applicants:
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
City or township governments
For profit organizations other than small businesses
Private institutions of higher education
Native American tribal governments (Federally recognized)
Special district governments
Small businesses
Independent school districts
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Public and State controlled institutions of higher education
State governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Public housing authorities/Indian housing authorities
County governments
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: This Funding Opportunity Announcement (FOA) invites applications for human studies to elucidate the etiology and pathogenesis of the increased risk for neurocognitive impairment associated with type 2 diabetes.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PAR-16-333.html
Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV
If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

Biophysical and Biomechanical Aspects of Embryonic Development (R01)

PAR-16-325
Biophysical and Biomechanical Aspects of Embryonic Development (R01)
Department of Health and Human ServicesebryoCapture

National Institutes of Health

Research Objectives

Research funded through this FOA will advance our knowledge of the biophysical and biomechanical factors that are critical for various aspects of morphogenesis during normal and abnormal embryonic development. Aberrations in morphogenesis result in a variety of structural birth defects. The purpose of this announcement is to invite applications designed to exploit innovative ideas for studying biophysical and mechanical processes contributing to embryonic development. This includes quantitative measurement of temporal changes in physical and mechanical properties of cells and tissues in living organisms, in relation to changes in their microenvironment.

Applicants should propose hypothesis-driven research in developmental biology. It should be noted that applications submitted to this R01 FOA should have sufficient preliminary data to substantiate the validity of the proposed research and use of new technologies. It is important to note that the goal of this FOA is to promote studies conducted in vivo, as emphasized below.

Background

The term ‘developmental mechanics’ refers to and emphasizes the importance of an orderly sequence of physical, chemical, and physiological mechanisms essential for normal embryonic development (His, 1874). In the past, research on developmental biomechanics was focused on developing theoretical models and using in vitro experimental approaches for model validation. However, it is now well recognized that morphogenesis occurs through interactions between multiple tissue layers, and physical parameters contributing to these processes are not displayed appropriately when studying individual cells in culture. The challenge is to match theoretical models to experimental data and integrate the analyses across time and space so that cellular mechanisms can be linked to tissue-level behavior. Consequently, to better understand the role of the physical and mechanical forces exerted during development, the focus of this FOA is to promote studies aimed at understanding biomechanics of morphogenesis in vivo.

In recent years, there has been considerable progress in understanding the genetic control of morphogenesis. It is evident that regulated gene expression determines the chemical environment of cells and tissues and thereby regulates biophysical processes. In turn, changes in physical forces feed back to regulate gene function and cell fate. Advancing our knowledge of the physical aspects of development will thus provide a broader view on how the genome of multicellular organisms functions in association with physical forces to specify final shape and architecture of an organ and/or an entire organism.

General Information

Document Type: Grants Notice
Funding Opportunity Number: PAR-16-325
Funding Opportunity Title: Biophysical and Biomechanical Aspects of Embryonic Development (R01)
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Grant
Category of Funding Activity: Health
Income Security and Social Services
Category Explanation:
Expected Number of Awards:
CFDA Number(s): 93.865 — Child Health and Human Development Extramural Research
Cost Sharing or Matching Requirement: No
Posted Date: Jun 10, 2016
Last Updated Date: Jun 10, 2016
Original Closing Date for Applications: Sep 19, 2018  
Current Closing Date for Applications: Sep 19, 2018  
Archive Date: Oct 20, 2018
Estimated Total Program Funding:
Award Ceiling: $500,000

Eligibility

Eligible Applicants:
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Private institutions of higher education
State governments
County governments
Public housing authorities/Indian housing authorities
Public and State controlled institutions of higher education
Small businesses
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Special district governments
Native American tribal organizations (other than Federally recognized tribal governments)
Native American tribal governments (Federally recognized)
City or township governments
For profit organizations other than small businesses
Independent school districts
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: This Funding Opportunity Announcement (FOA) encourages applications from institutions/organizations that propose to advance our knowledge in the area of the physics and mechanics of embryonic development. Applicants should propose hypothesis-driven developmental research with the prospect of gaining new and critical information about tissue mechanics relevant to vertebrate development and understanding the basis for developmental disorders. Investigators are encouraged to explore approaches and concepts new to the area of developmental tissue mechanics, and use newly developed techniques superior to the ones currently used in the field. It should be noted that applications submitted to this R01 FOA should have sufficient preliminary data to substantiate the validity of the proposed research and feasibility of new technologies or tools.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PAR-16-325.html
Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV
If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster