Limited Competition for the Continuation of the Scientific Data Research Center (SDRC) for the NIDDK Gastroparesis Consortium (U24)

RFA-DK-16-507
Limited Competition for the Continuation of the Scientific Data Research Center (SDRC) for the NIDDK Gastroparesis Consortium (U24)
Department of Health and Human Services
National Institutes of Health

Background

Gastroparesis is a chronic symptomatic disorder associated with delayed gastric emptying.

Gastroparesis predominantly affects young women (females outnumber males by a ratio of 4:1, the average age is 34). The symptomatic profile of gastroparesis includes nausea (90% of patients), vomiting (>80%), bloating (75%), early satiety (60%), and abdominal pain (~50%). Symptoms in individual patients can vary in both the combination of symptoms and their severity. Because of its chronic and often intractable nature, the disorder has a tremendous impact on both patients and society. Gastroparesis remains difficult to treat, in large part, because of the lack of knowledge of the underlying pathophysiology. Several factors have impeded the progress in this field including the paucity of patients seen by any one center, the absence of uniform diagnostic criteria, and the lack of generally available and reliable methods for physiological testing. Given the complexity of the problem, and the profound degree of morbidity associated with this disorder, an important need exists to study patients in a systematic manner. Such studies can best be achieved by recruiting patients and collecting data from multiple centers as part of a network of investigators focused on this disorder. In recognition of this fact, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) established the Gastroparesis Clinical Research Consortium (GpCRC) in 2006 and renewed the consortium in 2010. Since many gaps still existed despite the progress of the consortium, in April 2015, an External Scientific Committee recommended support of the Consortium activities for another 5 years.

Research Objectives
Through the acquisition of a cohort of well-characterized patients and associated biospecimens (blood, stools and when feasible gastric  tissue), the clinical research consortium  will provide the resources and collaborative opportunities necessary for achieving many of the research objectives identified in the strategic plan of NIDDK for Gastroparesis.

The overriding objective of this research program is to pursue clinical research on Gastroparesis  (both sporadic and  associated with diabetes mellitus type 1 and 2 and obesity), by identifying and characterizing a large cohort of patients with gastroparesis to encourage translational research focusing upon elucidating the pathogenesis that will provide the basis for understanding the natural history and developing means of diagnosis, treatment and clinical management of Gastroparesis  and its sequela: chronic abdominal pain, nausea, vomiting, poor metabolic control and impaired quality of life.

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-DK-16-507
Funding Opportunity Title: Limited Competition for the Continuation of the Scientific Data Research Center (SDRC) for the NIDDK Gastroparesis Consortium (U24)
Opportunity Category: Discretionary
Funding Instrument Type: Cooperative Agreement
Category of Funding Activity: Food and Nutrition
Health
Category Explanation:
Expected Number of Awards: 1
CFDA Number(s): 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research
Cost Sharing or Matching Requirement: No
Posted Date: Dec 22, 2015
Creation Date: Dec 22, 2015
Original Closing Date for Applications: Mar 2, 2016  
Current Closing Date for Applications: Mar 2, 2016  
Archive Date: Apr 2, 2016
Estimated Total Program Funding: $4,300,000
Award Ceiling: $1,000,000
Award Floor:

Eligibility

Eligible Applicants:
Private institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Public and State controlled institutions of higher education
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Additional Information

Agency Name: National Institutes of Health
Description: This Funding Opportunity Announcement (FOA) invites an application for the Scientific Data Research Center (SDRC) of the Gastroparesis Clinical Research Consortium (GpCRC). The purpose of this FOA is to allow additional follow-up of GpCRC participants. The companion FOA, RFA-DK-16-010 will support continuation of the GpCRC Clinical Centers (CC).
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-16-507.html
Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV
If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

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Small Grant Program for NIDDK K01/K08/K23 Recipients (R03)

PAR-15-343
Limited Competition: Small Grant Program for NIDDK K01/K08/K23 Recipients (R03)
Department of Health and Human ServicesNIDDK
National Institutes of Health

Section I. Funding Opportunity Description

The NIDDK encourages recipients of NIDDK-supported mentored career development awards (K01/K08/K23) to apply for grant support during the final two years of their awards through the NIDDK Small Grant Program (R03).  This additional support will enable K awardees to either expand their current research objectives or to branch out to a closely related pilot study, thus demonstrating their growth as investigators and their independence.  This should facilitate the transition to fully independent investigator status.  The added grant support in the latter years of a K award is expected to have the following benefits:

  • Increased fiscal independence for the award recipient as a precursor to complete independence.
  • An opportunity for the recipient to generate additional publications and data to support a subsequent R01 application.
  • An opportunity for the awardee to demonstrate additional success in the peer review process during the course of their career development award.

The NIDDK encourages every NIDDK-supported K01/K08/K23 recipient to apply for R01, or equivalent, grant support during the course of their career awards. According to NIH policy, K awardees may now receive concurrent salary support from an NIH career development award and a research grant under certain circumstances (http://grants1.nih.gov/grants/guide/notice-files/NOT-OD-08-065.html ).  However, any K01/K08/K23 recipient who receives an R01, or equivalent, grant will no longer be eligible to receive an R03 grant under this R03 program.  The definition of ‘equivalent’ R01 grant is also in NOT-OD-08-065.

General Information

Document Type: Grants Notice
Funding Opportunity Number: PAR-15-343
Funding Opportunity Title: Limited Competition: Small Grant Program for NIDDK K01/K08/K23 Recipients (R03)
Opportunity Category: Discretionary
Funding Instrument Type: Grant
Category of Funding Activity: Food and Nutrition
Health
Category Explanation:
Expected Number of Awards:
CFDA Number(s): 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research
Cost Sharing or Matching Requirement: No
Posted Date: Sep 9, 2015
Creation Date: Sep 9, 2015
Original Closing Date for Applications: Sep 7, 2018  
Current Closing Date for Applications: Sep 7, 2018  
Archive Date: Oct 8, 2018
Estimated Total Program Funding:
Award Ceiling:
Award Floor:

Eligibility

Eligible Applicants:
State governments
For profit organizations other than small businesses
Others (see text field entitled “Additional Information on Eligibility” for clarification)
City or township governments
Native American tribal governments (Federally recognized)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
Independent school districts
Public housing authorities/Indian housing authorities
Small businesses
County governments
Special district governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Public and State controlled institutions of higher education
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Additional Information

Agency Name: National Institutes of Health
Description: The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) announces a program that provides NIDDK-supported K01, K08, and K23 recipients the opportunity to apply for Small Grant (R03) support at some point during the final two years of their K award. Through the use of this mechanism, the NIDDK is seeking to enhance the capability of its K01, K08, and K23 award recipients to conduct research as they complete their transition to fully independent investigator status. The R03 grant mechanism supports different types of projects, including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology. The R03 is, therefore, intended to support research projects that can be carried out in a short period of time with limited resources and that may provide preliminary data to support a subsequent R01, or equivalent, application.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PAR-15-343.html