BRAIN Initiative: Data Archives for the BRAIN Initiative (R24)

RFA-MH-17-255
BRAIN Initiative: Data Archives for the BRAIN Initiative (R24)
Department of Health and Human Services
National Institutes of Health

Section I. Funding Opportunity Descriptionbrain
Background

The BRAIN Initiative: The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative® is aimed at revolutionizing our understanding of the human brain. By accelerating the development and application of innovative technologies, researchers will be able to produce a new dynamic picture of the brain that, for the first time, will show how individual cells and complex neural circuits interact in both time and space. It is expected that the application of these new tools and technologies will ultimately lead to new ways to treat and prevent brain disorders.

NIH is one of several federal agencies involved in the BRAIN Initiative. Planning for the NIH component of the BRAIN initiative is guided by the long-term scientific plan, “BRAIN 2025: A Scientific Vision,” which details seven high-priority research areas and calls for a sustained federal commitment of $4.5 billion over 12 years. This FOA and other FOAs issued in Fiscal Year 2017 are based on careful consideration by the NIH of the recommendations of the BRAIN 2025 Report, and input from the NIH BRAIN Multi-Council Working Group.  Videocasts of the NIH BRAIN Multi-council Working Group are available at http://www.braininitiative.nih.gov/about/mcwg.htm.

To enable rapid progress in development of new technologies as well as in theory and data analysis, the BRAIN Initiative encourages collaborations between neurobiologists and scientists from statistics, physics, mathematics, engineering, and computer and information sciences; and NIH welcomes applications from investigators in these disciplines.

NIH encourages BRAIN Initiative applications from investigators that are underrepresented in the biomedical, behavioral, or clinical research workforce (see data athttp://www.nsf.gov/statistics/showpub.cfm?TopID=2&SubID=27 and the most recent report on Women, Minorities, and Persons with Disabilities in Science and Engineering). Such individuals include those from underrepresented racial and ethnic groups, those with disabilities, and those from disadvantaged backgrounds.

NIH also encourages businesses to participate in the BRAIN Initiative.  It is possible for companies to submit applications directly to BRAIN Initiative program announcements or to collaborate with academic researchers in joint submissions.  Small businesses should consider applying to one of the BRAIN Initiative small business FOAs (http://braininitiative.nih.gov/funding/index.htm).

In addition to the National BRAIN initiative, the NIH continues to have a substantial annual investment in neuroscience research. The Institutes and Centers contributing to the NIH BRAIN Initiative (http://braininitiative.nih.gov/ ) support those research efforts through investigator-initiated applications as well as through specific FOAs. Potential applicants to this FOA are strongly encouraged to contact Scientific/Research staff if they have any questions about the best FOA for their research.

The BRAIN Initiative will require a high level of coordination and sharing between investigators. It is expected that BRAIN Initiative awardees will cooperate and coordinate their activities after awards are made by participating in Program Director/Principal Investigator (PD/PI) meetings and in other activities.

This FOA is related to the recommendations in Section III.5 of the BRAIN 2025 Report.  Specifically, this FOA solicits applications that will address the recommendations on “Identifying Fundamental Principles”.

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-MH-17-255
Funding Opportunity Title: BRAIN Initiative: Data Archives for the BRAIN Initiative (R24)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Grant
Category of Funding Activity: Education
Health
Income Security and Social Services
Category Explanation:  
Expected Number of Awards:  
CFDA Number(s): 93.173 — Research Related to Deafness and Communication Disorders
93.213 — Research and Training in Complementary and Integrative Health
93.242 — Mental Health Research Grants
93.273 — Alcohol Research Programs
93.279 — Drug Abuse and Addiction Research Programs
93.286 — Discovery and Applied Research for Technological Innovations to Improve Human Health
93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders
93.865 — Child Health and Human Development Extramural Research
93.866 — Aging Research
93.867 — Vision Research
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Sep 21, 2016
Last Updated Date: Sep 21, 2016
Original Closing Date for Applications: Oct 19, 2017  
Current Closing Date for Applications: Oct 19, 2017  
Archive Date: Nov 19, 2017
Estimated Total Program Funding:  
Award Ceiling:  
Award Floor:

Eligibility

Eligible Applicants: For profit organizations other than small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
County governments
Independent school districts
Special district governments
Public housing authorities/Indian housing authorities
Small businesses
Private institutions of higher education
City or township governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
State governments
Native American tribal governments (Federally recognized)
Public and State controlled institutions of higher education
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: This Funding Opportunity Announcement (FOA) solicits applications to develop web-accessible data archives to capture, store, and curate data related to BRAIN Initiative activities. The data archives will work with the research community to incorporate tools that allow users to analyze and visualize the data, but the creation of such tools is not part of this FOA. The data archives will use appropriate standards to describe the data, but the creation of such standards is not part of this FOA. A goal of this program is to advance research by creating a community resource data archive with appropriate standards and summary information that is broadly available and accessible to the research community for furthering research.
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-17-255.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

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High Impact Neuroscience Research Resource Grants (R24)

RFA-NS-17-002
High Impact Neuroscience Research Resource Grants (R24)
Department of Health and Human Services
National Institutes of Health

Section I. Funding Opportunity Descriptionneuroscience
Goals

Research project grants such as the R01 provide funding for development of new technologies and resources.  However, funding opportunities for making resources available to the research community are more limited, even though such activities can be critical for research progress.  The goal of this FOA is to address this need by supporting innovative and high impact projects to make resources, tools and techniques available to neuroscience researchers.

Projects responsive to this FOA should engage one or more of the following types of activities:

  • Propagation of recently developed, cutting edge reagents or techniques that are not widely available or easily obtained
  • Broadening the impact of important existing resources by bringing them to new user groups for whom access would not otherwise be available
  • Innovative approaches to increase the scale and efficiency of existing valuable resources.

The following categories of resources may be appropriate for this FOA, provided that the proposed resource concords with the types of high impact activities described above: animal models, animal surgery, behavioral testing, specialized cell culture, histochemistry, specialized imaging or microscopy, pathology, physiology, and statistical/computational analysis.

Applicants are strongly encouraged to contact NINDS Program staff and/or the Scientific/Research Contact for this FOA (Section VII, below) to discuss the potential relevance of a particular resource to this FOA.

Scope:

Proposed projects must plan to substantially impact the quality of neuroscience research by virtue of the provided resources.  Existing efforts are responsive to this FOA provided the application proposes specific plans for new high impact activities that would not otherwise be feasible. Technical improvements to existing strategies can be proposed if they enable or increase the scale and efficiency of dissemination.

Efforts must be in support of the NINDS mission, which is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. In pursuit of this mission, NINDS supports and performs basic, translational, and clinical neuroscience research through grants-in-aid, contracts, scientific meetings, and through research in its own laboratories, and clinics; funds and conducts research training and career development programs to increase basic, translational and clinical neuroscience expertise and ensure a vibrant, talented, and diverse work force; and promotes the timely dissemination of scientific discoveries and their implications for neurological health to the public, health professionals, researchers, and policy-makers.  For more information on NINDS research funding listed by Program Area, seehttp://www.ninds.nih.gov/funding/areas/index.htm.

Projects must be specifically targeted to neuroscience (or neuromuscular) research.  Resources and techniques that are general to biomedical sciences are not responsive to this FOA, unless there is a specific unmet neuroscience research need.

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-NS-17-002
Funding Opportunity Title: High Impact Neuroscience Research Resource Grants (R24)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Grant
Category of Funding Activity: Health
Category Explanation:  
Expected Number of Awards: 5
CFDA Number(s): 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Sep 21, 2016
Last Updated Date: Sep 21, 2016
Original Closing Date for Applications: Feb 14, 2017  
Current Closing Date for Applications: Feb 14, 2017  
Archive Date: Mar 17, 2017
Estimated Total Program Funding: $1,200,000
Award Ceiling: $350,000
Award Floor:  

Eligibility

Eligible Applicants: Public and State controlled institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Independent school districts
Others (see text field entitled “Additional Information on Eligibility” for clarification)
State governments
County governments
Special district governments
Public housing authorities/Indian housing authorities
Private institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Native American tribal governments (Federally recognized)
City or township governments
For profit organizations other than small businesses
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Small businesses
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Additional Information

Agency Name: National Institutes of Health
Description: This funding opportunity announcement (FOA) supports high impact efforts to make resources available to neuroscience researchers. Projects should engage in one or more of the following activities: facilitating access to cutting edge reagents or techniques, dissemination of resources to new user groups, or innovative approaches to increase the scale/efficiency of resource production and delivery. Applications focused primarily on technology or software development are not responsive to this FOA, as the focus is on dissemination or provision of resources. Use of existing technologies to develop new reagents or genetic lines of significant value to the research community may be appropriate. Projects should address compelling needs of broad communities of neuroscience researchers or should offer unique services that otherwise would be unavailable. Projects must support the NINDS mission.
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-17-002.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

NeuroNEXT Clinical Trials (U01)

PAR-16-155
NeuroNEXT Clinical Trials (U01)
Department of Health and Human Services
National Institutes of Health

Scope of the Program

This FOA encourages applications for exploratory clinical trials of investigational agents (drugs, biologics, surgical therapies or devices) required for designing a future trial, for biomarker validation studies, or for proof of mechanism clinical studies.  Applications for drugs or biologics should provide compelling scientific evidence that the investigational agent proposed for study will reach/act upon the designated target or that its mechanism of action is such that it is expected to be of benefit in ameliorating a specific aspect of the disease. Neurologic diseases chosen for study must fall within the primary responsibility of NINDS (http://www.ninds.nih.gov/disorders/disorder_index.htm).

Examples of appropriate studies under this FOA include, but are not limited to, those designed to:

  • Evaluate and optimize the dose, formulation, safety, tolerability or pharmacokinetics of an intervention in the target population.
  • Evaluate whether an intervention produces sufficient evidence of short-term activity (e.g., biomarker activity, pharmacodynamic response, target engagement, dose-response trends) in a human “proof of concept” trial.
  • Select or rank the best of two or more potential interventions or dosing regimens to be evaluated in a subsequent trial, based on tolerability, safety data, biological activity, or preliminary clinical efficacy (e.g., futility trials).
  • Evaluate biological activity relative to clinical endpoints.
  • For medical devices, in addition to providing initial clinical safety data, appropriate studies are those that inform the next phase of development, usually by finalizing the device design, establishing operator technique, and/or finalizing the choice of study endpoints for the design of a pivotal clinical trial.

Studies in stroke prevention, treatment and/or recovery are not appropriate for inclusion in  NeuroNEXT. All multi-site stroke studies will be conducted in the NINDS-funded stroke trials network (http://www.ninds.nih.gov/research/clinical_research/NINDS_stroke_trials_network.htm).

neurology

 

General Information

Document Type: Grants Notice
Funding Opportunity Number: PAR-16-155
Funding Opportunity Title: NeuroNEXT Clinical Trials (U01)
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Cooperative Agreement
Category of Funding Activity: Health
Category Explanation:
Expected Number of Awards:
CFDA Number(s): 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders
Cost Sharing or Matching Requirement: No
Posted Date: Mar 28, 2016
Last Updated Date: Mar 28, 2016
Original Closing Date for Applications: Aug 03, 2017  
Current Closing Date for Applications: Aug 03, 2017  
Archive Date: Sep 03, 2017
Estimated Total Program Funding:
Award Ceiling:
Award Floor:

Eligibility

Eligible Applicants:
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
For profit organizations other than small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
State governments
City or township governments
Public housing authorities/Indian housing authorities
Special district governments
County governments
Private institutions of higher education
Small businesses
Native American tribal governments (Federally recognized)
Independent school districts
Public and State controlled institutions of higher education
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: This FOA encourages applications for exploratory clinical trials of investigational agents (drugs, biologics, surgical therapies or devices) that may contribute to the justification for and provide the data required for designing a future trial, for biomarker validation studies, or for proof of mechanism clinical studies. Diseases chosen for study should be based on the NINDS’ strategic plan and clinical research interests (www.ninds.nih.gov/funding/areas/index.htm). Successful applicants will be given access to the NeuroNEXT infrastructure. Following peer review, NINDS will prioritize and order trials that are given access to the NeuroNEXT infrastructure. The NeuroNEXT Clinical Coordinating Center (CCC) will work with the successful applicant to efficiently implement the proposed study. The NeuroNEXT Data Coordinating Center (DCC) will provide statistical and data management support. The NeuroNEXT clinical sites will provide recruitment/retention support as well as on-site implementation of the clinical protocol. Applicants do not need to be part of the existing NeuroNEXT infrastructure.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PAR-16-155.html
Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV
If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster