BRAIN Initiative: Data Archives for the BRAIN Initiative (R24)

RFA-MH-17-255
BRAIN Initiative: Data Archives for the BRAIN Initiative (R24)
Department of Health and Human Services
National Institutes of Health

Section I. Funding Opportunity Descriptionbrain
Background

The BRAIN Initiative: The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative® is aimed at revolutionizing our understanding of the human brain. By accelerating the development and application of innovative technologies, researchers will be able to produce a new dynamic picture of the brain that, for the first time, will show how individual cells and complex neural circuits interact in both time and space. It is expected that the application of these new tools and technologies will ultimately lead to new ways to treat and prevent brain disorders.

NIH is one of several federal agencies involved in the BRAIN Initiative. Planning for the NIH component of the BRAIN initiative is guided by the long-term scientific plan, “BRAIN 2025: A Scientific Vision,” which details seven high-priority research areas and calls for a sustained federal commitment of $4.5 billion over 12 years. This FOA and other FOAs issued in Fiscal Year 2017 are based on careful consideration by the NIH of the recommendations of the BRAIN 2025 Report, and input from the NIH BRAIN Multi-Council Working Group.  Videocasts of the NIH BRAIN Multi-council Working Group are available at http://www.braininitiative.nih.gov/about/mcwg.htm.

To enable rapid progress in development of new technologies as well as in theory and data analysis, the BRAIN Initiative encourages collaborations between neurobiologists and scientists from statistics, physics, mathematics, engineering, and computer and information sciences; and NIH welcomes applications from investigators in these disciplines.

NIH encourages BRAIN Initiative applications from investigators that are underrepresented in the biomedical, behavioral, or clinical research workforce (see data athttp://www.nsf.gov/statistics/showpub.cfm?TopID=2&SubID=27 and the most recent report on Women, Minorities, and Persons with Disabilities in Science and Engineering). Such individuals include those from underrepresented racial and ethnic groups, those with disabilities, and those from disadvantaged backgrounds.

NIH also encourages businesses to participate in the BRAIN Initiative.  It is possible for companies to submit applications directly to BRAIN Initiative program announcements or to collaborate with academic researchers in joint submissions.  Small businesses should consider applying to one of the BRAIN Initiative small business FOAs (http://braininitiative.nih.gov/funding/index.htm).

In addition to the National BRAIN initiative, the NIH continues to have a substantial annual investment in neuroscience research. The Institutes and Centers contributing to the NIH BRAIN Initiative (http://braininitiative.nih.gov/ ) support those research efforts through investigator-initiated applications as well as through specific FOAs. Potential applicants to this FOA are strongly encouraged to contact Scientific/Research staff if they have any questions about the best FOA for their research.

The BRAIN Initiative will require a high level of coordination and sharing between investigators. It is expected that BRAIN Initiative awardees will cooperate and coordinate their activities after awards are made by participating in Program Director/Principal Investigator (PD/PI) meetings and in other activities.

This FOA is related to the recommendations in Section III.5 of the BRAIN 2025 Report.  Specifically, this FOA solicits applications that will address the recommendations on “Identifying Fundamental Principles”.

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-MH-17-255
Funding Opportunity Title: BRAIN Initiative: Data Archives for the BRAIN Initiative (R24)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Grant
Category of Funding Activity: Education
Health
Income Security and Social Services
Category Explanation:  
Expected Number of Awards:  
CFDA Number(s): 93.173 — Research Related to Deafness and Communication Disorders
93.213 — Research and Training in Complementary and Integrative Health
93.242 — Mental Health Research Grants
93.273 — Alcohol Research Programs
93.279 — Drug Abuse and Addiction Research Programs
93.286 — Discovery and Applied Research for Technological Innovations to Improve Human Health
93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders
93.865 — Child Health and Human Development Extramural Research
93.866 — Aging Research
93.867 — Vision Research
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Sep 21, 2016
Last Updated Date: Sep 21, 2016
Original Closing Date for Applications: Oct 19, 2017  
Current Closing Date for Applications: Oct 19, 2017  
Archive Date: Nov 19, 2017
Estimated Total Program Funding:  
Award Ceiling:  
Award Floor:

Eligibility

Eligible Applicants: For profit organizations other than small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
County governments
Independent school districts
Special district governments
Public housing authorities/Indian housing authorities
Small businesses
Private institutions of higher education
City or township governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
State governments
Native American tribal governments (Federally recognized)
Public and State controlled institutions of higher education
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: This Funding Opportunity Announcement (FOA) solicits applications to develop web-accessible data archives to capture, store, and curate data related to BRAIN Initiative activities. The data archives will work with the research community to incorporate tools that allow users to analyze and visualize the data, but the creation of such tools is not part of this FOA. The data archives will use appropriate standards to describe the data, but the creation of such standards is not part of this FOA. A goal of this program is to advance research by creating a community resource data archive with appropriate standards and summary information that is broadly available and accessible to the research community for furthering research.
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-17-255.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

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High Impact Neuroscience Research Resource Grants (R24)

RFA-NS-17-002
High Impact Neuroscience Research Resource Grants (R24)
Department of Health and Human Services
National Institutes of Health

Section I. Funding Opportunity Descriptionneuroscience
Goals

Research project grants such as the R01 provide funding for development of new technologies and resources.  However, funding opportunities for making resources available to the research community are more limited, even though such activities can be critical for research progress.  The goal of this FOA is to address this need by supporting innovative and high impact projects to make resources, tools and techniques available to neuroscience researchers.

Projects responsive to this FOA should engage one or more of the following types of activities:

  • Propagation of recently developed, cutting edge reagents or techniques that are not widely available or easily obtained
  • Broadening the impact of important existing resources by bringing them to new user groups for whom access would not otherwise be available
  • Innovative approaches to increase the scale and efficiency of existing valuable resources.

The following categories of resources may be appropriate for this FOA, provided that the proposed resource concords with the types of high impact activities described above: animal models, animal surgery, behavioral testing, specialized cell culture, histochemistry, specialized imaging or microscopy, pathology, physiology, and statistical/computational analysis.

Applicants are strongly encouraged to contact NINDS Program staff and/or the Scientific/Research Contact for this FOA (Section VII, below) to discuss the potential relevance of a particular resource to this FOA.

Scope:

Proposed projects must plan to substantially impact the quality of neuroscience research by virtue of the provided resources.  Existing efforts are responsive to this FOA provided the application proposes specific plans for new high impact activities that would not otherwise be feasible. Technical improvements to existing strategies can be proposed if they enable or increase the scale and efficiency of dissemination.

Efforts must be in support of the NINDS mission, which is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. In pursuit of this mission, NINDS supports and performs basic, translational, and clinical neuroscience research through grants-in-aid, contracts, scientific meetings, and through research in its own laboratories, and clinics; funds and conducts research training and career development programs to increase basic, translational and clinical neuroscience expertise and ensure a vibrant, talented, and diverse work force; and promotes the timely dissemination of scientific discoveries and their implications for neurological health to the public, health professionals, researchers, and policy-makers.  For more information on NINDS research funding listed by Program Area, seehttp://www.ninds.nih.gov/funding/areas/index.htm.

Projects must be specifically targeted to neuroscience (or neuromuscular) research.  Resources and techniques that are general to biomedical sciences are not responsive to this FOA, unless there is a specific unmet neuroscience research need.

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-NS-17-002
Funding Opportunity Title: High Impact Neuroscience Research Resource Grants (R24)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Grant
Category of Funding Activity: Health
Category Explanation:  
Expected Number of Awards: 5
CFDA Number(s): 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Sep 21, 2016
Last Updated Date: Sep 21, 2016
Original Closing Date for Applications: Feb 14, 2017  
Current Closing Date for Applications: Feb 14, 2017  
Archive Date: Mar 17, 2017
Estimated Total Program Funding: $1,200,000
Award Ceiling: $350,000
Award Floor:  

Eligibility

Eligible Applicants: Public and State controlled institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Independent school districts
Others (see text field entitled “Additional Information on Eligibility” for clarification)
State governments
County governments
Special district governments
Public housing authorities/Indian housing authorities
Private institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Native American tribal governments (Federally recognized)
City or township governments
For profit organizations other than small businesses
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Small businesses
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Additional Information

Agency Name: National Institutes of Health
Description: This funding opportunity announcement (FOA) supports high impact efforts to make resources available to neuroscience researchers. Projects should engage in one or more of the following activities: facilitating access to cutting edge reagents or techniques, dissemination of resources to new user groups, or innovative approaches to increase the scale/efficiency of resource production and delivery. Applications focused primarily on technology or software development are not responsive to this FOA, as the focus is on dissemination or provision of resources. Use of existing technologies to develop new reagents or genetic lines of significant value to the research community may be appropriate. Projects should address compelling needs of broad communities of neuroscience researchers or should offer unique services that otherwise would be unavailable. Projects must support the NINDS mission.
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-17-002.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

Metabolic Contributions to the Neurocognitive Complications of Diabetes: Ancillary Studies (R01)

PAR-16-333
Metabolic Contributions to the Neurocognitive Complications of Diabetes: Ancillary Studies (R01)
Department of Health and Human Services
National Institutes of Health

cognitive-neuroscience-cognitive_neuroscience

Section I. Funding Opportunity Description

The purpose of this Funding Opportunity Announcement (FOA) is to elucidate the etiology and pathogenesis of the neurocognitive complications associated with type 2 diabetes (T2D) with the ultimate goal of informing future strategies to mitigate the risk of these complications. Applications should propose expansions of ongoing human studies of well characterized T2D cohorts or cohorts comparing T2D with non-diabetic populations.  Such expansions might include the addition of comprehensive neurocognitive measures (e.g., cognitive testing, neuroimaging, and biomarkers), clinical measures (e.g., insulin resistance, HbA1c), and/or collection of data on other risk factors (e.g., diet, obesity, micro- and macro-vascular disease, inflammation). It must be clearly explained how the collection of additional data will contribute to elucidation of the basis of neurocognitive sequelae of T2D.

Background: Emerging data have established links between T2D and neurocognitive impairment, including dementia. The current epidemic of dementia is driven, at least in part, by the concurrent epidemics of obesity, insulin resistance, T2D, and metabolic syndrome. Early research sought to elucidate the cause(s) for the apparent role of metabolic dysfunction in the increased prevalence of neurocognitive dysfunction and dementia, tentatively attributed to vascular contributions to cognitive impairment and dementia (VCID) and Alzheimer’s disease (AD). Recent neuropathological research indicates that less than half of the variability in cognitive impairment in the years prior to death may be attributable to AD and other common pathologies, and it is unclear which pathologies are the primary drivers of the association between T2D and neurocognitive impairment and dementia.

Unlike other complications of T2D, neurocognitive complications of T2D have not clearly been demonstrated to correlate with measures of peripheral glycemia (with the exception of very poor glycemic control, HbA1c > 10%) and there is even less evidence for an association with other measures of peripheral glucose regulation (e.g., insulin concentration, insulin action, insulin resistance). The dearth of large-scale studies involving longitudinal assessment of T2D and associated risk factors for complications, neurocognition, and disease management has limited our knowledge of how specific parameters associated with T2D may lead to changes in brain structure and function and deficits in cognition, and how susceptibility to these brain changes may vary across the lifespan.  Moreover, it can be difficult to distinguish the etiology of cognitive impairment since individuals with T2D are at increased risk of other associated complications (e.g., obesity, micro- and macro-vascular disease) that can affect cognition. Recent advances in neuroimaging, computerized neurocognitive assessment, and the availability of large, well-characterized cohorts with T2D could lead to improvements in characterizing brain structure/function, cognition, and clinical parameters and other risk factors associated with T2D.  If specific parameters and other risk factors for adverse neurocognitive outcomes associated with T2D could be defined, treatment protocols could be developed to limit neurocognitive complications associated with T2D.

Types of ancillary studies might include, but are not limited to:

Addition of metabolic and clinical phenotyping in individuals with T2D (e.g., measurement of insulin resistance, HbA1c), including associated factors of relevance to neurocognitive complications of T2D (e.g., diet, obesity, micro- and macro-vascular disease, inflammation), to studies that are already obtaining detailed measurement of neurocognition.

Addition of cohorts with T2D and associated metabolic disease (insulin resistance, prediabetes) to studies that are already obtaining detailed measurement of neurocognition.

Addition of comprehensive neurocognitive measures (e.g., cognitive testing, neuroimaging, and fluid-based biomarkers) to existing studies of T2D cohorts with well-characterized clinical correlates and course of disease.

Regardless of the type of study design, there must be a plan to measure the variables of interest in the same cohort at a minimum of two well justified time points. Cross sectional and purely correlative research is not consistent with the goals of this initiative.

Research that can examine how genetic and environmental factors confer risk or protect against the neurocognitive complications of T2D is encouraged. Research that addresses how neurocognitive complications of T2D impact academic and occupational function (where relevant) and activities of daily living, including the relationship to management of disease and/or treatment adherence is also encouraged.

Research across the lifespan and healthspan is appropriate for this FOA; however, it is possible that due to aging and disease-related factors, isolating mechanisms may be more complex and clinical targets less modifiable as individuals advance in age and disease burden increases. Therefore, there will be a special emphasis on research earlier in the developmental spectrum, especially prior to the development of complex disease (e.g., severe complications of T2D, CVD, dementia).

Strong expertise in T2D and associated disease processes (obesity, insulin resistance, prediabetes) and neuroscience is important for the research teams that will carry out the research supported by this FOA. It is anticipated that many of the funded research studies will involve the analysis and interpretation of complex, high-dimensional datasets. Therefore, it is strongly encouraged to include data scientists with relevant expertise on the research team. Collaborations between basic and clinical scientists are also encouraged but not required.

This FOA is NOT intended to fund the following:

  • New clinical trials to test the efficacy of interventions for neurocognitive complications of T2D.
  • Animal studies.
  • Projects that need a new or separate clinical research infrastructure for sample collection and subject recruitment.  Projects that use samples or subjects from restricted clinical studies; such as those for which access to resources is only permitted to consortium members, or those that place restrictions on publications or data access that are inconsistent with NIH policy.
  • Core activities of ongoing clinical studies.

General Information

Document Type: Grants Notice
Funding Opportunity Number: PAR-16-333
Funding Opportunity Title: Metabolic Contributions to the Neurocognitive Complications of Diabetes: Ancillary Studies (R01)
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Grant
Category of Funding Activity: Food and Nutrition
Health
Category Explanation:
Expected Number of Awards:
CFDA Number(s): 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research
Cost Sharing or Matching Requirement: No
Posted Date: Jun 15, 2016
Last Updated Date: Jun 15, 2016
Original Closing Date for Applications: Sep 07, 2019  
Current Closing Date for Applications: Sep 07, 2019  
Archive Date: Oct 08, 2019

Eligibility

Eligible Applicants:
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
City or township governments
For profit organizations other than small businesses
Private institutions of higher education
Native American tribal governments (Federally recognized)
Special district governments
Small businesses
Independent school districts
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Public and State controlled institutions of higher education
State governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Public housing authorities/Indian housing authorities
County governments
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: This Funding Opportunity Announcement (FOA) invites applications for human studies to elucidate the etiology and pathogenesis of the increased risk for neurocognitive impairment associated with type 2 diabetes.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PAR-16-333.html
Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV
If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

NeuroNEXT Clinical Trials (U01)

PAR-16-155
NeuroNEXT Clinical Trials (U01)
Department of Health and Human Services
National Institutes of Health

Scope of the Program

This FOA encourages applications for exploratory clinical trials of investigational agents (drugs, biologics, surgical therapies or devices) required for designing a future trial, for biomarker validation studies, or for proof of mechanism clinical studies.  Applications for drugs or biologics should provide compelling scientific evidence that the investigational agent proposed for study will reach/act upon the designated target or that its mechanism of action is such that it is expected to be of benefit in ameliorating a specific aspect of the disease. Neurologic diseases chosen for study must fall within the primary responsibility of NINDS (http://www.ninds.nih.gov/disorders/disorder_index.htm).

Examples of appropriate studies under this FOA include, but are not limited to, those designed to:

  • Evaluate and optimize the dose, formulation, safety, tolerability or pharmacokinetics of an intervention in the target population.
  • Evaluate whether an intervention produces sufficient evidence of short-term activity (e.g., biomarker activity, pharmacodynamic response, target engagement, dose-response trends) in a human “proof of concept” trial.
  • Select or rank the best of two or more potential interventions or dosing regimens to be evaluated in a subsequent trial, based on tolerability, safety data, biological activity, or preliminary clinical efficacy (e.g., futility trials).
  • Evaluate biological activity relative to clinical endpoints.
  • For medical devices, in addition to providing initial clinical safety data, appropriate studies are those that inform the next phase of development, usually by finalizing the device design, establishing operator technique, and/or finalizing the choice of study endpoints for the design of a pivotal clinical trial.

Studies in stroke prevention, treatment and/or recovery are not appropriate for inclusion in  NeuroNEXT. All multi-site stroke studies will be conducted in the NINDS-funded stroke trials network (http://www.ninds.nih.gov/research/clinical_research/NINDS_stroke_trials_network.htm).

neurology

 

General Information

Document Type: Grants Notice
Funding Opportunity Number: PAR-16-155
Funding Opportunity Title: NeuroNEXT Clinical Trials (U01)
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Cooperative Agreement
Category of Funding Activity: Health
Category Explanation:
Expected Number of Awards:
CFDA Number(s): 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders
Cost Sharing or Matching Requirement: No
Posted Date: Mar 28, 2016
Last Updated Date: Mar 28, 2016
Original Closing Date for Applications: Aug 03, 2017  
Current Closing Date for Applications: Aug 03, 2017  
Archive Date: Sep 03, 2017
Estimated Total Program Funding:
Award Ceiling:
Award Floor:

Eligibility

Eligible Applicants:
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
For profit organizations other than small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
State governments
City or township governments
Public housing authorities/Indian housing authorities
Special district governments
County governments
Private institutions of higher education
Small businesses
Native American tribal governments (Federally recognized)
Independent school districts
Public and State controlled institutions of higher education
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: This FOA encourages applications for exploratory clinical trials of investigational agents (drugs, biologics, surgical therapies or devices) that may contribute to the justification for and provide the data required for designing a future trial, for biomarker validation studies, or for proof of mechanism clinical studies. Diseases chosen for study should be based on the NINDS’ strategic plan and clinical research interests (www.ninds.nih.gov/funding/areas/index.htm). Successful applicants will be given access to the NeuroNEXT infrastructure. Following peer review, NINDS will prioritize and order trials that are given access to the NeuroNEXT infrastructure. The NeuroNEXT Clinical Coordinating Center (CCC) will work with the successful applicant to efficiently implement the proposed study. The NeuroNEXT Data Coordinating Center (DCC) will provide statistical and data management support. The NeuroNEXT clinical sites will provide recruitment/retention support as well as on-site implementation of the clinical protocol. Applicants do not need to be part of the existing NeuroNEXT infrastructure.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PAR-16-155.html
Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV
If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

NIH Blueprint Training in Computational Neuroscience: From Biology to Model and Back Again (T90/R90)

RFA-DA-16-009
NIH Blueprint Training in Computational Neuroscience: From Biology to Model and Back Again (T90/R90)
Department of Health and Human Services
National Institutes of Health

comp neuro.png

Purpose and Background Information The overall goal of the NIH Ruth L. Kirschstein National Research Service Award (NRSA) program is to help ensure that a diverse pool of highly trained scientists is available in appropriate scientific disciplines to address the Nation’s biomedical, behavioral, and clinical research needs.  In order to accomplish this goal, NRSA training programs are designed to train individuals to conduct research and to prepare for research careers. The NIH Research Education Program (R90) supports research educational activities that complement other formal training programs in the mission areas of the NIH Institutes and Centers.

Institutional training programs allow the Training Program Director/Principal Investigator (Training PD/PI) to select the trainees and develop a program of coursework, research experiences, and technical and/or professional skills development appropriate for the selected trainees. Each program should provide high-quality research training and offer opportunities in addition to conducting mentored research. The grant offsets the cost of stipends, tuition and fees, and training related expenses, including health insurance, for the appointed trainees in accordance with the approved NIH support levels.

Blueprint Training in Computational Neuroscience

The National Institutes of Health (NIH) Blueprint for Neuroscience Research is a collaborative and coordinated effort across 13 Institutes and Centers that support research, research education, and research training with the goal of accelerating the pace of discovery in neuroscience research. By pooling resources and expertise, the NIH Blueprint for Neuroscience Research can take advantage of economies of scale, confront challenges too large for any specific Institute or Center, and develop research tools and infrastructure that will serve the entire neuroscience community.

An exciting and difficult challenge in neuroscience is to understand how complex biological systems work, and particularly to understand the computational principles and mechanisms underlying the function of the nervous system in both normal and diseased states. Another challenge lies in interpreting the massive amount and extremely complex experimental data obtained by today’s advanced neuroscience research, which traditional analytical approaches are not sophisticated enough to handle. Computational neuroscience provides a theoretical foundation and set of technological approaches to meet these challenges and offers significant opportunities to investigate and integrate information about nervous system function across a range of scales: parts of cells, networks, whole brain function, and behavior. Two major obstacles have been identified to the training of computational neuroscientists. The first impediment is that individuals trained in the biological and behavioral sciences often do not have adequate background in the quantitative sciences. This education needs to begin as early as possible, ideally at the undergraduate level, and continue through graduate and postdoctoral levels to ensure a good foundation in quantitative science and the ability to adopt new computational theory and methodology as they emerge. Second, students with undergraduate degrees in the quantitative sciences often have little exposure to the exciting questions and experimental methods in the neurosciences to which their training would be highly relevant. A research education and research training program that begins early and exposes students to a wide range of neuroscience questions, methods, and experimental systems would help to overcome this second obstacle.

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-DA-16-009
Funding Opportunity Title: NIH Blueprint Training in Computational Neuroscience: From Biology to Model and Back Again (T90/R90)
Opportunity Category: Discretionary
Funding Instrument Type: Grant
Category of Funding Activity: Education
Environment
Health
Income Security and Social Services
Category Explanation:
Expected Number of Awards:
CFDA Number(s): 93.113 — Environmental Health
93.121 — Oral Diseases and Disorders Research
93.213 — Research and Training in Complementary and Integrative Health
93.242 — Mental Health Research Grants
93.273 — Alcohol Research Programs
93.279 — Drug Abuse and Addiction Research Programs
93.286 — Discovery and Applied Research for Technological Innovations to Improve Human Health
93.361 — Nursing Research
93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders
93.865 — Child Health and Human Development Extramural Research
93.866 — Aging Research
93.867 — Vision Research
Cost Sharing or Matching Requirement: No
Posted Date: Jan 13, 2016
Creation Date: Jan 13, 2016
Original Closing Date for Applications: Mar 18, 2016  
Current Closing Date for Applications: Mar 18, 2016  
Archive Date: Apr 18, 2016
Estimated Total Program Funding: $1,500,000
Award Ceiling: $500,000
Award Floor:

Eligibility

Eligible Applicants:
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal governments (Federally recognized)
State governments
Public housing authorities/Indian housing authorities
Public and State controlled institutions of higher education
Additional Information on Eligibility: See full announcement for complete details.

Additional Information

Agency Name: National Institutes of Health
Description: This Funding Opportunity Announcement (FOA) is an initiative of the NIH Blueprint for Neuroscience Research (http://neuroscienceblueprint.nih.gov/), a collaborative and coordinated effort across 13 Institutes and Centers that support research, research education, and research training with the goal of accelerating the pace of discovery in neuroscience research. This FOA will support integrated research education and research training programs that provide interdisciplinary training in experimental neuroscience and the theoretical and technological approaches of computational neuroscience at the undergraduate and predoctoral level.
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-16-009.html
Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

eRA Service Desk Monday to Friday 7 am to 8 pm ET http://grants.nih.gov/support/ Phone 1-866-504-9552
Grants Info

Neuroimaging Informatics Tools and Resources Clearinghouse (U24)

RFA-EB-16-002
Neuroimaging Informatics Tools and Resources Clearinghouse (U24)
Department of Health and Human Services
National Institutes of Health

disorders-of-the-brain-and-nervous-system

Background

The Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) (http://www.nitrc.org), originally funded by the NIH Blueprint for Neuroscience Research in 2006, is a dynamic inventory of web-based neuroimaging informatics resources: software, data, and tools accessible via any computer connected to the internet. The purpose of the NITRC project is to promote the enhancement, sharing, adoption, and evolution of neuroimaging informatics tools and resources by providing access, information, and forums for interaction for the user community and the associated developers. The NITRC project was designed to improve scientific research and promote sharing of previously funded research and initiatives and to encourage community interaction and collaboration. NITRC facilitates finding and comparing neuroimaging resources for functional and structural neuroimaging analyses. The goals of NITRC are to catalog and point to standardized information about neuroimaging tools, or resources. In 2011, the scope of NITRC was expanded to provide enhanced services such as virtual computing, and data storage.

The functionality of the Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) has enabled three distinct components to flourish

  • NITRC-R: the NITRC resource for software and tool exchange.
  • NITRC-IR: the NITRC image repository of publicly accessible, anonymized, and curated, clinical neuroimaging data.
  • NITRC-CE: the NITRC compute environment permitting researchers around the globe the ability to do computations on neuroimaging datasets.

NITRC-R has become the major web-based collaborative environment enabling the distribution, enhancement, and adoption of neuroinformatics resources. It currently hosts more than 748 tools and resources in areas such as magnetic resonance imaging (MRI), electroencephalography (EEG),  magnetoencephalography (MEG), multi-modal, positron emission tomography, single photon emission computed tomography (PET / SPECT), computed tomography (CT), clinical neuroinformatics, imaging genomics, optical imaging, and computation neuroscience.

NITRC-IR currently comprises a curated repository of more than 6,000 human subjects’ DICOM and NIfTI-1 images, which are searchable by metadata such as handedness, gender, and grouping. This data is registered on INCF Dataspace and is a Tier 3 resource on the Neuroscience Information Framework (NIF). NITRC-IR is the data repository for the 1000 Functional Connectomes (resting state), the ABIDE study (resting state), CANDIShare (T1 and manual segmentations), ADHD200 (resting state), INDI NKI/Rockland (resting state), PING (structural, diffusion, and resting state), CoRR (test-retest reliability and reproducibility), as well as international studies such as Beijing Enhanced DTI, Beijing Eyes Open Eyes Closed, Beijing Short TR study, Study Forrest rev003 (structural brain scans, physiological measurements, technical confounds), IXI study (normal, healthy subjects MRI scans).

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-EB-16-002
Funding Opportunity Title: Neuroimaging Informatics Tools and Resources Clearinghouse (U24)
Opportunity Category: Discretionary
Funding Instrument Type: Cooperative Agreement
Category of Funding Activity: Education
Environment
Health
Income Security and Social Services
Category Explanation:
Expected Number of Awards: 1
CFDA Number(s): 93.113 — Environmental Health
93.213 — Research and Training in Complementary and Integrative Health
93.242 — Mental Health Research Grants
93.273 — Alcohol Research Programs
93.279 — Drug Abuse and Addiction Research Programs
93.286 — Discovery and Applied Research for Technological Innovations to Improve Human Health
93.361 — Nursing Research
93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders
93.865 — Child Health and Human Development Extramural Research
93.866 — Aging Research
93.867 — Vision Research
Cost Sharing or Matching Requirement: No
Posted Date: Jan 13, 2016
Creation Date: Jan 13, 2016
Original Closing Date for Applications: Mar 15, 2016  
Current Closing Date for Applications: Mar 15, 2016  
Archive Date: Apr 15, 2016
Estimated Total Program Funding: $600,000
Award Ceiling:
Award Floor:

Eligibility

Eligible Applicants:
Native American tribal governments (Federally recognized)
Public and State controlled institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
For profit organizations other than small businesses
Special district governments
State governments
County governments
Private institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Additional Information on Eligibility: See full announcement for complete details.

Additional Information

Agency Name: National Institutes of Health
Description: The purpose of this FOA is to support the Neuroimaging Informatics Tools and Resources Clearinghouse and to enable collaborative research in neuroimaging informatics
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-EB-16-002.html
Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

eRA Service Desk Monday to Friday 7 am to 8 pm ET http://grants.nih.gov/support/ Phone 1-866-504-9552
Grants Info

High Impact Neuroscience Research Resource Grants (R24)

RFA-NS-16-005neuroscience

High Impact Neuroscience Research Resource Grants (R24)
Department of Health and Human Services
National Institutes of Health

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-NS-16-005
Funding Opportunity Title: High Impact Neuroscience Research Resource Grants (R24)
Opportunity Category: Discretionary
Funding Instrument Type: Grant
Category of Funding Activity: Health
Category Explanation:
Expected Number of Awards: 5
CFDA Number(s): 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders
Cost Sharing or Matching Requirement: No
Posted Date: Aug 31, 2015
Creation Date: Aug 31, 2015
Original Closing Date for Applications: Dec 9, 2015  
Current Closing Date for Applications: Dec 9, 2015  
Archive Date: Jan 9, 2016
Estimated Total Program Funding: $1,200,000
Award Ceiling:
Award Floor:

Eligibility

Eligible Applicants:
Public and State controlled institutions of higher education
For profit organizations other than small businesses
Public housing authorities/Indian housing authorities
Independent school districts
Native American tribal governments (Federally recognized)
State governments
Small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
Special district governments
County governments
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
City or township governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name: National Institutes of Health
Description: This funding opportunity announcement (FOA) supports high impact efforts to make resources available to neuroscience researchers. Projects should engage in one or more of the following activities: propagation of cutting edge reagents or techniques, dissemination of resources to new user groups, or innovative approaches to increase the scale/efficiency of resource production and delivery. Applications focused on technology or software development are not responsive to this FOA, as the focus is on dissemination or provision of resources. Use of existing technologies to develop new reagents or genetic lines of clear value may be appropriate. Projects should address compelling needs of broad communities of neuroscience researchers or should offer unique services that otherwise would be unavailable. Projects must support the NINDS mission.
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-16-005.html
Goals

Research project grants such as the R01 provide funding for development of new technologies and resources.  However, funding opportunities for making resources available to the research community are more limited, even though such activities can be critical for research progress.  The goal of this FOA is to address this need by supporting innovative and high impact projects to make resources, tools and techniques available to neuroscience researchers.

Projects responsive to this FOA should engage one or more of the following types of activities:

  • Propagation of newly developed, cutting edge reagents or techniques that are not widely available or easily obtained
  • Broadening the impact of important existing resources by bringing them to new user groups for whom access would not otherwise be available
  • Innovative approaches to increase the scale and efficiency of existing valuable resources.

The following categories of resources may be appropriate for this FOA, provided that the proposed resource concords with the types of high impact activities described above: Animal models, Animal Surgery, Behavioral Testing, Specialized Cell Culture, Histochemistry, Specialized Imaging or Microscopy, Pathology, Physiology, and Statistical/Computational Analysis.

Applicants are strongly encouraged to contact NINDS Program staff and/or the Scientific/Research Contact for this FOA (Section VII, below) to discuss the potential relevance of a particular resource to this FOA.

Scope

Proposed projects must plan to substantially impact the quality of neuroscience research by virtue of the provided resources.  Existing efforts are responsive to this FOA provided the application proposes specific plans for new high impact activities that would not otherwise be feasible. Technical improvements to existing strategies can be proposed if they enable or increase the scale and efficiency of dissemination.

Efforts must be in support of the NINDS mission, which is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. In pursuit of this mission, NINDS supports and performs basic, translational, and clinical neuroscience research through grants-in-aid, contracts, scientific meetings, and through research in its own laboratories, and clinics; funds and conducts research training and career development programs to increase basic, translational and clinical neuroscience expertise and ensure a vibrant, talented, and diverse work force; and promotes the timely dissemination of scientific discoveries and their implications for neurological health to the public, health professionals, researchers, and policy-makers.  For more information on NINDS research funding listed by Program Area, see http://www.ninds.nih.gov/funding/areas/index.htm.

Projects must be specifically targeted to neuroscience research.  Resources and techniques that are general to biomedical sciences are not responsive to this FOA, unless there is a specific unmet neuroscience research need.

The following activities are not responsive to this FOA.

  • Projects focused on technology development are not responsive to this FOA.  Applicants considering such efforts are encouraged to contact an appropriate NINDS Program Director to discuss alternative grant mechanisms.  Use of existing technologies to develop new reagents, such as genetic lines or constructs, may be appropriate for this FOA, but clear value to the intended user group must be demonstrated in the application.
  • Projects focused solely on software development are not responsive to this FOA.  Applicants considering software development efforts can find information on current funding announcements and NIH Program contacts at the Biomedical Information Science and Technology Initiative (BISTI) website (http://www.bisti.nih.gov).
  • Projects that support clinical trials or provide patient services are not responsive to this FOA.  For services associated with clinical research, investigators should contact the NINDS Office of Clinical Research (http://www.ninds.nih.gov/research/clinical_research/).
  • Projects that provide funding for chemistry services associated with candidate therapeutic lead optimization are not responsive to this FOA.  For services associated with translational research, investigators should contact the NINDS Office of Translational Research (http://www.ninds.nih.gov/funding/areas/translational_research/index.htm).
  • Projects proposing repositories of brain and related bio-specimens are not responsive to this FOA, as described in NOT-MH-12-020.