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Multi-Site Studies for System-Level Implementation of Substance Use Prevention and Treatment Services (R01)

PAR-16-455
Multi-Site Studies for System-Level Implementation of Substance Use Prevention and Treatment Services (R01)
Department of Health and Human Services
National Institutes of Health

Section I. Funding Opportunity DescriptionRx-Drugs

Implementation science is a growing field. An early area of emphasis for addiction health services researchers was to move beyond training of individual clinicians or service providers as a default implementation strategy, and develop interventions that would achieve broader, sustainable implementation at the organizational level. Some research has begun to look at intra-organizational implementation strategies to further accelerate the implementation of evidence-based practices (or de-implementation of unsupported or harmful practices). However, to date, a major remaining challenge is how to facilitate – in a systematic, scalable, sustainable way – the delivery of evidence-based prevention and treatment services at a system level.

This FOA seeks research projects that will move beyond a focus on how individual clinics or organizations implement a given change, and beyond implementation of interventions that target only a single evidence-based intervention (EBI). The purpose of this FOA is to identify efficacious and effective strategies or techniques for facilitating systems-level change within or across networks of organizations to promote broad use of evidence-based practices for the prevention and/or treatment of substance use disorders or HIV. This FOA seeks applications that can address implementation on a larger, system-level scale that is more analogous to the way policy changes lead to system-level changes in prevention and treatment service delivery. Achieving system-level improvements requires implementation strategies that are sufficiently flexible to address the variation in settings and context across a given system, but that are also generalizable across settings. The multi-site studies supported by this FOA should contribute both practical and conceptual advances.  In practical terms, these studies should provide strategies that can be used to effectively deploy guidelines, practices, and policies across entire systems of care.  In conceptual terms, these studies should also leverage the multi-site platform to test implementation science hypotheses, explore novel methodological approaches, or test new measures or models that can inform future implementation research in this or other health domains.

General Information

Document Type: Grants Notice
Funding Opportunity Number: PAR-16-455
Funding Opportunity Title: Multi-Site Studies for System-Level Implementation of Substance Use Prevention and Treatment Services (R01)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Grant
Category of Funding Activity: Education
Health
Category Explanation:  
Expected Number of Awards:  
CFDA Number(s): 93.273 — Alcohol Research Programs
93.279 — Drug Abuse and Addiction Research Programs
93.399 — Cancer Control
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Sep 30, 2016
Last Updated Date: Sep 30, 2016
Original Closing Date for Applications: Nov 13, 2020  
Current Closing Date for Applications: Nov 13, 2020  
Archive Date: Dec 14, 2020
Estimated Total Program Funding:  
Award Ceiling: $500,000
Award Floor:

Eligibility

Eligible Applicants: Public housing authorities/Indian housing authorities
City or township governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
State governments
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Independent school districts
Public and State controlled institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
For profit organizations other than small businesses
County governments
Private institutions of higher education
Native American tribal governments (Federally recognized)
Special district governments
Small businesses
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Additional Information

Agency Name: National Institutes of Health
Description: As part of the Collaborative Research on Addiction at NIH (CRAN) initiative, NIDA, NIAAA, and NCI join to issue this FOA. The purpose of this FOA is to support the development and testing of interventions, models, and/or frameworks that examine system-level implementation of evidence-based interventions, guidelines, or principles to improve the delivery, uptake, quality, and sustainability of substance use prevention and treatment interventions and services.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PAR-16-455.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

Data Integration and Analysis Tools: Accessible Resources for Integration and Analysis of Carbohydrate and Glycoconjugate Data in the Context of Comparable Gene, Protein, and Lipid Data (U01)

RFA-RM-16-021
Data Integration and Analysis Tools: Accessible Resources for Integration and Analysis of Carbohydrate and Glycoconjugate Data in the Context of Comparable Gene, Protein, and Lipid Data (U01)
Department of Health and Human Services
National Institutes of Health

successful-grant-writing-strategies-for-an-r-award-15-638

Research Objectives and Scope

The analysis and integration of carbohydrate and glycoconjugate data is a complex challenge. Present computational and informatics technologies for carbohydrate analysis are decades behind those developed for nucleic acids and proteins. Like other aspects of glycobiology, progress in glycoinformatics is sporadic and fragmented. The resulting tools are primitive, and poorly integrated, and adoption by non-specialists has been slow. Certain glycoinformatics tools, such as glycan structure databases, have been developed. These databases, however, are limited and balkanized, and are not matched with tools for interrogating the databases in meaningful ways. They are also not well-integrated with databases for proteins or genomic information. Other classes of glycoinformatics tools are in their infancy, or entirely lacking. Examples include algorithms for spectral interpretation to support glycoconjugate structure determination, or interpretation of glycan array binding data.

Recent community-led efforts to arrive at standardization of glycan nomenclature as expressed in databases, interoperability of databases, and reporting of experimental metadata have been promising. Two important features of these recent efforts are: (1) they have been inclusive, community-driven projects, and (2) they have focused on preserving the utility of the tools already created.  Efforts to bring glycoinformatics up to the current state of the art available for the other classes of biological macromolecules must be grounded in a clearly articulated vision for addressing the significant challenges confronting the field, and facilitate participation of many independent research groups. The project should create an environment that enables current and future software developers to join this effort with a clear understanding of the framework within which their contributions will be most effective.

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-RM-16-021
Funding Opportunity Title: Data Integration and Analysis Tools: Accessible Resources for Integration and Analysis of Carbohydrate and Glycoconjugate Data in the Context of Comparable Gene, Protein, and Lipid Data (U01)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Cooperative Agreement
Category of Funding Activity: Health
Category Explanation:  
Expected Number of Awards: 1
CFDA Number(s): 93.310 — Trans-NIH Research Support
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Sep 16, 2016
Last Updated Date: Sep 16, 2016
Original Closing Date for Applications: Nov 28, 2016  
Current Closing Date for Applications: Nov 28, 2016  
Archive Date: Dec 29, 2016
Estimated Total Program Funding: $2,000,000
Award Ceiling: $1,500,000
Award Floor:

Eligibility

Eligible Applicants: City or township governments
Special district governments
Public housing authorities/Indian housing authorities
Native American tribal governments (Federally recognized)
Native American tribal organizations (other than Federally recognized tribal governments)
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For profit organizations other than small businesses
State governments
Independent school districts
Public and State controlled institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Small businesses
County governments
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name: National Institutes of Health
Description: The Common Fund Program – Accelerating Translation of Glycoscience: Integration and Accessibility – aims to develop accessible and affordable new tools and technologies for studying carbohydrates that will allow biomedical researchers to significantly advance our understanding of the roles of these complex molecules in health and disease. This program will enable investigators who might not otherwise conduct research in the glycosciences, to undertake the study of carbohydrate structure and function.
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-16-021.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

NIAID Career Transition Award (K22)

PAR-14-341
NIAID Career Transition Award (K22)
Department of Health and Human Servicesmulti-ethnic-scientists-in-lab-article
National Institutes of Health

Section I. Funding Opportunity Description

The overall goal of the NIH Research Career Development program is to help ensure that a diverse pool of highly trained scientists is available in appropriate scientific disciplines to address the Nation’s biomedical, behavioral, and clinical research needs. In addition to this opportunity, NIH Institutes and Centers (ICs) support a variety of other mentored career development programs designed to foster the transition of new investigators to research independence. These other programs may be more suitable for particular candidates.  NIH also supports non-mentored career development programs for independent investigators. More information about Career programs may be found at the NIH Extramural Training Mechanisms website.

The objective of the of the NIAID Career Transition Award is to support postdoctoral fellows transitioning to positions of assistant professor or equivalent, and initiate a successful biomedical career as an independent research scientist.

NIH believes that the creativity and innovation of new independent investigators in their early career stages play an integral role in addressing our Nation’s biomedical, behavioral, and clinical research needs. However, the average age of first-time (new) Principal Investigators obtaining R01 research funding from the NIH has risen to 42 years for Ph.D. degree holders and 44 years for M.D./Ph.D. degree holders in 2013. The intent of the NIAID K22 program is to help alleviate this trend and to assist new investigators in transitioning to stable independent research positions at an earlier age and with an enhanced probability of success in obtaining independent NIH or other independent research support.

Nature of the career/research transition opportunity

The K22 award will provide two years of support to conduct biomedical research as an independent scientist at an extramural sponsoring institution/organization to which the individual has been recruited, been offered and has accepted a tenure-track full-time assistant professor position (or equivalent). This support is to allow the individual to continue to work toward establishing his/her own independent research program and prepare an application for regular research grant support (R01).

The postdoctoral fellow, also referred to as a candidate, submits a K22 application from the institution where s/he currently pursues his/her postdoctoral research training.  The application will be peer reviewed and assigned an overall impact score.  Successful candidates (i.e. whose application has received a fundable overall impact score) will receive an approval letter from NIAID that will include the terms and conditions to activate the K22 award. In order to activate the K22 award, the candidate will need to secure a tenure-track full-time assistant professor position within a year of the receipt of the approval letter.  Once the assistant professor position has been secured, the candidate will submit updated information about the K22 application with the support of the sponsoring institution.  The sponsoring institution can be the same as the post-doctoral institution, though it is most likely a different institution from the original submission of the K22 application.  The updated information of the transition to an assistant professor position at the sponsoring institution will be evaluated by senior NIAID staff to ensure that all programmatic requirements are met prior to the activation of the K22 award. The details of the requirements for the activation of the K22 award are described in Section VI of this announcement.

General Information

Document Type: Grants Notice
Funding Opportunity Number: PAR-14-341
Funding Opportunity Title: NIAID Career Transition Award (K22)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Grant
Category of Funding Activity: Health
Category Explanation:  
Expected Number of Awards:  
CFDA Number(s): 93.855 — Allergy, Immunology and Transplantation Research
93.856 — Microbiology and Infectious Diseases Research
Cost Sharing or Matching Requirement: No
Version: Synopsis 2
Posted Date: Sep 12, 2014
Last Updated Date: Sep 16, 2016
Original Closing Date for Applications: Sep 07, 2017  
Current Closing Date for Applications: Sep 16, 2016  
Archive Date: Oct 16, 2016
Estimated Total Program Funding:  
Award Ceiling:  
Award Floor:  

Eligibility

Eligible Applicants: Small businesses
Special district governments
County governments
City or township governments
Native American tribal governments (Federally recognized)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Independent school districts
Public housing authorities/Indian housing authorities
For profit organizations other than small businesses
Public and State controlled institutions of higher education
Private institutions of higher education
State governments
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Native American tribal organizations (other than Federally recognized tribal governments)
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name: National Institutes of Health
Description: The purpose of the NIAID Career Transition Award (CTA) program is to increase and maintain a strong cohort of new and talented NIH-supported independent investigators that will address the health needs of the Nation. The NIAID CTA is specifically designed to facilitate the transition from a postdoctoral research position to an independent research position.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PAR-14-341.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

Intramural NIGMS Postdoctoral Research Associate (PRAT) Program (Fi2)

PAR-16-130
Intramural NIGMS Postdoctoral Research Associate (PRAT) Program (Fi2)
Department of Health and Human Services
National Institutes of Health

Section I. Funding Opportunity Descriptionresearch-funding-process

The overall goal of the Intramural NIGMS Postdoctoral Research Associate (PRAT) program is to help ensure that a diverse pool of highly trained scientists is available in appropriate scientific disciplines to address the Nation’s biomedical research needs. The NIGMS PRAT Program can be found at the website http://www.nigms.nih.gov/Training/Pages/PRAT.aspx. In 1965, the first cohort of postdoctoral fellows entered the NIGMS PRAT Program to begin a period of research training in the NIH Intramural Research Program.  Since this time, numerous PRAT alumni have become leaders in their respective fields and across multiple career sectors.  Although this program grew out of a desire to train more individuals in the field of pharmacology, the program has broadened over time and now supports all research areas within the mission of NIGMS.  In 2012, the name of the program was changed to the Postdoctoral Research Associate (PRAT) Program in recognition of the diversity of disciplines supported by the program, but the core features of the program remain the same.  The NIGMS PRAT Program continues to provide access to excellent research, mentoring, and career development resources in the NIH Intramural Research Program and maintains a focus on training leaders in the basic biomedical sciences.

The NIGMS PRAT Program’s overarching goal is to provide high-quality research training in the basic biomedical sciences, in NIH intramural research laboratories, to a diverse group of postdoctoral fellows to prepare them for leadership positions in biomedical careers. This training includes a mentored laboratory experience as well as intensive career and leadership development activities.  Fellows selected for the NIGMS PRAT Program will receive three years of support from this mechanism.

The NIGMS PRAT Program will support fellowship training within the NIH Intramural Research Program that is focused on NIGMS mission-related areas of basic biomedical science. These include but are not limited to cell biology, biophysics, genetics, developmental biology, pharmacology, physiology, biological chemistry, computational biology, technology development and bioinformatics. Studies employing model organisms are encouraged.  Fellows can conduct this work in any of the NIH Institutes or Centers with an Intramural Research Program, with mentors who have relevant experience in these areas of research.  This arrangement allows fellows from a wide array of diverse scientific disciplines to interact on a regular basis and to exchange ideas.

The NIGMS PRAT program distinguishes itself from other postdoctoral training opportunities on the NIH campus through its approach to cultivating the next generation of leaders in the basic biomedical sciences.  Fellows selected for this program are from a wide array of basic biomedical research disciplines.  The fellows interact on a regular basis to present their research and exchange ideas during a monthly seminar series combining a research presentation from a current PRAT fellow with a presentation from an outside speaker.  This communication across disciplines fosters discussion of new research approaches and a deeper appreciation of the contributions these diverse disciplines make to the basic biomedical research enterprise.  The program further broadens the experience of participating fellows by providing intensive mentoring and defined career development activities focused on topics such as leadership skills, oral presentations, and grant-writing as part of the training curriculum.   Fellows selected for the PRAT program are required to participate in the PRAT-sponsored training activities.  The PRAT Program Director(s) oversees all activities of the NIGMS PRAT Program and provides additional mentoring to PRAT fellows.

NIGMS PRAT fellows are encouraged to broaden their training by attending scientific seminars on the NIH campus, traveling to scientific meetings, participating actively in lab meetings, making scientific presentations and publishing the results of their research. Fellows receive formal training in the ethical conduct of research and scientific methods, including a focus on the reproducibility of data. All fellows are strongly encouraged to take courses in quantitative biology and statistics, if they have not already done so. Fellows are exposed broadly to the cutting-edge technologies for which the intramural program is noted.

General Information

Document Type: Grants Notice
Funding Opportunity Number: PAR-16-130
Funding Opportunity Title: Intramural NIGMS Postdoctoral Research Associate (PRAT) Program (Fi2)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Grant
Category of Funding Activity: Health
Category Explanation:  
Expected Number of Awards:  
CFDA Number(s): 93.859 — Biomedical Research and Research Training
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Sep 07, 2016
Last Updated Date: Sep 07, 2016
Original Closing Date for Applications: Oct 03, 2018  
Current Closing Date for Applications: Oct 03, 2018  
Archive Date: Nov 03, 2018
Estimated Total Program Funding:  
Award Ceiling:  
Award Floor:

Eligibility

Eligible Applicants: State governments
City or township governments
County governments
Special district governments
Additional Information on Eligibility: Other Eligible Applicants include the following: Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Additional Information

Agency Name: National Institutes of Health
Description: The NIGMS Postdoctoral Research Associate (PRAT) Programs overarching goal is to provide high quality postdoctoral research training in the basic biomedical sciences, in NIH intramural research laboratories, to a diverse group of postdoctoral fellows to prepare them for leadership positions in biomedical careers. The research projects proposed should focus on NIGMS mission-related areas of basic biomedical science. These include cell biology, biophysics, genetics, developmental biology, pharmacology, physiology, biological chemistry, computational biology, technology development and bioinformatics. Studies employing model organisms are encouraged.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PAR-16-130.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

Six Research Grants are Available from NORD for the Study of Rare Diseases

Reminder: Six Research Grants are Available from NORD for the Study of Rare Diseases

pic

These grants are made possible by donations to NORD. In some cases, the grants are co-sponsored by NORD and disease-specific patient organizations. NORD encourages all U.S. and international researchers interested in studying these diseases to consider applying.

  • Alveolar Capillary Dysplasia with Misalignment of the Pulmonary Veins – One (1) grant of up to $50,000, for scientific and/or clinical research studies related to Alveolar Capillary Dysplasia (ACD/MPV). See full RFP and abstract template here.
  • Appendix Cancer and Pseudomyxoma Peritonei – Two (2) grants of up to $50,000 for scientific and/or clinical research studies related to Appendix Cancer and/or Pseudomyxoma Peritonei (PMP). See full RFP and abstract template here.
  • Autoimmune Polyglandular Syndrome Type 1 – One (1) grant of up to $100,000 for scientific and/or clinical research studies related to Autoimmune Polyglandular Syndrome Type 1 (APS Type 1). See full RFP and abstract template here.
  • Homocystinuria – One (1) grant of up to $30,000 for scientific and/or clinical research studies related to Homocystinuria due to Cystathionine Beta-Synthase Deficiency. See full RFP and abstract template here.
  • Malonic Aciduria – One (1) grant of up to $30,000 for scientific and/or clinical research studies related to Malonic Aciduria. See full RFP and abstract template here.
  • Stiff Person Syndrome – One (1) grant of up to $30,000 for scientific and/or clinical research studies related to Stiff Person Syndrome. See full RFP and abstract template here.

For more information about NORD’s research grant program and rare disease research funding opportunities, visit: http://rarediseases.org/requests-proposals.

“High” or “Medium” Priority AIDS Research on Non-AIDS-defining or AIDS-defining Cancers (R21)

PA-16-425
“High” or “Medium” Priority AIDS Research on Non-AIDS-defining or AIDS-defining Cancers (R21)
Department of Health and Human

Print Services
National Institutes of Health

Section I. Funding Opportunity Description
Purpose

The purpose of this funding opportunity announcement (FOA) is to continue advancing our understanding of the risks, development, progression, diagnosis, and treatment of malignancies observed in individuals with an underlying human immunodeficiency (HIV) infection or acquired immunodeficiency syndrome (AIDS), particularly the non-AIDS defining malignancies which are now a leading cause of death in HIV-infected individuals.

This FOA encourages high or medium priority AIDS research in areas such as the study of the etiologic factors, cofactors, immunopathogenesis, diagnosis, and consequences of both non-AIDS defining and AIDS-defining malignancies in populations with an underlying HIV infection.

This FOA encourages research efforts that will (i) identify specific contributions resulting from HIV infection and its potential interaction with other pathogens for the development and pathogenesis of these cancers and (ii) provide information on the clinical outcomes of such cancers in the HIV-infected population.

Ultimately, such efforts could inform screening approaches and therapies targeted to the HIV-infected population.

This FOA utilizes the Exploratory/Developmental Grant (R21) mechanism, which supports investigation of novel scientific ideas or new model systems, tools, or technologies that have the potential for significant impact on biomedical or biobehavioral research. An R21 grant application need not have extensive background material or preliminary information.

This FOA runs in parallel with another FOA of identical scientific scope, PA-16-426, which utilizes the Exploratory/Developmental Grant (R01) mechanism.

Scope

In 2015, NIH and OAR mandated that in the future, AIDS funds can only be used in for research addressing “high” or “medium” priority areas of AIDS research as defined in NOT-OD-15-137“NIH HIV/AIDS Research Priorities and Guidelines for Determining AIDS Funding”.

Topics considered “low priority” AIDS in NOT-OD-15-137 are not appropriate for this PAR except basic research in tumors caused by KSHV has, for the moment, been considered as “high priority” AIDS and will be eligible for funding under this PAR.  All applications considered for funding will be reviewed by OAR and must be aligned with the priorities in NOT-OD-15-137.

Specific areas of study in the indicated categories may include, but are not limited to, the following examples:

A) Biomarkers, Diagnostics, and Therapeutics:

  • Discovery of reliable molecular and immunological diagnostic and prognostic biomarkers and pathogen markers, useful for early detection, progression, or response to treatment of non-AIDS-defining and AIDS-defining malignancies;
  • Discovery and development of novel targets and efficacious new therapeutic agents, interventional strategies, or improved delivery systems for the treatment of cancer in people with HIV infection, however clinical trials are not permitted;
  • Studies to understand the pharmacokinetics of targeted therapies for AIDS-defining and non-AIDS defining malignancies in the context of highly active antiretroviral therapy and;
  • Studies utilizing existing cohorts and tissue banks of human specimens from a wide spectrum of AIDS-defining and non-AIDS defining malignancies to develop biomarker, diagnostic assays, or analyze samples and data acquired from these cohorts is encouraged. Examples of such cohorts and repositories include:
  • AIDS and Cancer Specimen Resource (ACSR),
  • Women’s Interagency HIV Study (WIHS)),
  • Veterans Aging Cohort Study (VACS)
  • Multicenter AIDS Cohort Study (MACS).

Investigators are also encouraged to utilize infrastructure support of the Centers for AIDS Research (CFAR) or NCI designated Cancer Centers if located at those institutions.

However, descriptive research and recruitment or retention of cohorts are not appropriate for this FOA.

General Information

Document Type: Grants Notice
Funding Opportunity Number: PA-16-425
Funding Opportunity Title: “High” or “Medium” Priority AIDS Research on Non-AIDS-defining or AIDS-defining Cancers (R21)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Grant
Category of Funding Activity: Education
Health
Category Explanation:  
Expected Number of Awards:  
CFDA Number(s): 93.121 — Oral Diseases and Disorders Research
93.393 — Cancer Cause and Prevention Research
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Sep 07, 2016
Last Updated Date: Sep 07, 2016
Original Closing Date for Applications: Sep 07, 2019  
Current Closing Date for Applications: Sep 07, 2019  
Archive Date: Oct 08, 2019
Estimated Total Program Funding:  
Award Ceiling: $200,000
Award Floor:

Eligibility

Eligible Applicants: Special district governments
Small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
Public and State controlled institutions of higher education
County governments
Independent school districts
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For profit organizations other than small businesses
Public housing authorities/Indian housing authorities
State governments
City or township governments
Native American tribal governments (Federally recognized)
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: The purpose of this funding opportunity announcement (FOA) is to continue advancing our understanding of the risks, development, progression, diagnosis, and treatment of malignancies observed in individuals with an underlying human immunodeficiency (HIV) infection or acquired immunodeficiency syndrome (AIDS), particularly the non-AIDS defining malignancies which are now a leading cause of death in HIV-infected individuals. This FOA encourages high or medium priority AIDS research in areas such as the study of the etiologic factors, cofactors, immunopathogenesis, diagnosis, and consequences of both non-AIDS defining and AIDS-defining malignancies in populations with an underlying HIV infection.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PA-16-425.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster