BRAIN Initiative: Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain (R01)

RFA-MH-17-220
BRAIN Initiative: Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain (R01)
Department of Health and Human Services
National Institutes of Health

neuron

Research Objectives

This funding opportunity announcement (FOA) is designed to support development and validation of novel tools to facilitate the detailed analysis of cells and circuits and provide insights into the neural circuitry and structure underlying complex behaviors. The human brain consists of an estimated one hundred billion neurons and more than one trillion supporting glial cells that are uniquely organized to confer the extraordinary computational activities of the brain. Cell types are categorized by their anatomical position, neurotransmitter content, dendritic and axonal connections, receptor profile, gene expression profile and distinct electrical properties. Although the human brain has long been the focus of numerous studies with many major achievements along the way, to date we remain largely ignorant about the specific details such as cell types and connections that are responsible for rapid information processing. Defining cellular and circuit-level function is dependent on detailed knowledge about the components and structure of the circuit. Such knowledge, in turn, is fundamental to understanding how these features underlie cognition and behavior, which should aid in the development of targeted cell-type and circuit-specific therapeutics to treat brain disorders. This initiative is focused on developing tools (or vastly improving existing tools) to enable access to individual cells and defined groups of cells within neuronal circuits. The tools sought through this FOA can include novel genetic or non-genetic methods for targeted delivery of genes, proteins, and chemicals to specific cells or tightly defined cell types and circuits.

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-MH-17-220
Funding Opportunity Title: BRAIN Initiative: Development and Validation of Novel Tools to Analyze Cell-Specific and Circuit-Specific Processes in the Brain (R01)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Grant
Category of Funding Activity: Education
Health
Income Security and Social Services
Category Explanation:  
Expected Number of Awards:  
CFDA Number(s): 93.173 — Research Related to Deafness and Communication Disorders
93.213 — Research and Training in Complementary and Integrative Health
93.242 — Mental Health Research Grants
93.273 — Alcohol Research Programs
93.279 — Drug Abuse and Addiction Research Programs
93.286 — Discovery and Applied Research for Technological Innovations to Improve Human Health
93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders
93.865 — Child Health and Human Development Extramural Research
93.866 — Aging Research
93.867 — Vision Research
Cost Sharing or Matching Requirement: No
Version: Synopsis 2
Posted Date: Aug 10, 2016
Last Updated Date: Sep 16, 2016
Original Closing Date for Applications: Nov 02, 2016  
Current Closing Date for Applications: Oct 13, 2017  
Archive Date: Nov 12, 2017
Estimated Total Program Funding:  
Award Ceiling:  
Award Floor:  

Eligibility

Eligible Applicants: Private institutions of higher education
State governments
Special district governments
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
County governments
Small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
Independent school districts
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Others (see text field entitled “Additional Information on Eligibility” for clarification)
City or township governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
For profit organizations other than small businesses
Public housing authorities/Indian housing authorities
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Tools that can be used in a number of species/model organisms rather than those restricted to a single species are highly desired. Applications that provide approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged.
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-17-220.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

Global Brain and Nervous System Disorders Research Across the Lifespan (R01)

PAR-14-332disorders-of-the-brain-and-nervous-system

Global Brain and Nervous System Disorders Research Across the Lifespan (R01) 

Funding Opportunity Purpose

This Funding Opportunity Announcement (FOA) encourages grant applications for the conduct of innovative, collaborative research projects between U.S. and low- and middle-income country (LMIC) scientists, on brain and other nervous system function and disorders throughout life, relevant to LMICs. Scientists in upper middle income countries (UMICs) are eligible to partner directly with scientists at other LMIC institutions. Income categories are defined by the World Bank at http://data.worldbank.org/about/country-classifications/country-and-lending-groups .

The collaborative research programs are expected to contribute to the long-term goals of building sustainable research capacity in LMICs to address nervous system development, function and impairment throughout life and to lead to diagnostics, prevention, treatment and implementation strategies. The proposed work will also contribute to developing a base for research networking and evidence-based policy beyond the specific research project.

Application Due Date(s)

January 5, 2015; January 5, 2016; January 5, 2017, by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

AIDS Application Due Date(s)

January 5, 2015; January 5, 2016; January 5, 2017 by 5:00 PM local time of applicant organization.

Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Scientific Merit Review

March 2015, March 2016, March 2017

Advisory Council Review

May 2015, May 2016, May 2017

Earliest Start Date

June 2015

Expiration Date

January 6, 2017

Research Topics

Relevant research topics for this FOA are related to nervous system function and/or impairment from birth to advanced age and across generations. Applicants are especially encouraged to propose research on co-morbidities and conditions that affect nervous system function at different life stages, as well as across the lifespan. Relevant research for these applications may range from basic science to epidemiological, clinical, health services and translational (e.g. translation of basic research to therapy and of clinical research to applications in the field) and implementation research. Applicants may propose a research and capacity building program on some aspect of nervous system function and/or impairment at any stage of life.

Examples of nervous system disorders contributing to the burden of disease in LMICs and relevant to this FOA, include but are not limited to, neuro-developmental disorders (including autism, cerebral palsy, fetal alcohol syndrome, learning disabilities), neurodegenerative diseases (such as Alzheimer’s and Parkinson’s Diseases), addictive disorders, seizure disorders such as epilepsy, neuropsychiatric disorders (such as unipolar depression, bipolar disorder, schizophrenia), posttraumatic stress disorder, dementias, encephalopathy, peripheral neuropathies, sensory and motor neuron diseases.

Examples of influences on nervous system function across the lifespan include, but are not limited to: genetic predispositions and epigenetic changes  in response to pre-, peri- and post-natal trauma and environmental factors (such as maternal depression, in-utero drug and alcohol exposure, neuro-toxic insults, perinatal hypoxia, child abuse and neglect, inadequate environmental stimulation and nutritional deficiencies),  physical and psychological trauma (exposure to violence, sexual and  physical abuse, traumatic nervous system injury due to violence and accidents), infection of the nervous system by viral and parasitic diseases (such as HIV/AIDS, malaria, neuro-cysticercosis) and stroke. Other factors affecting healthy brain development include access to appropriate health care and socioeconomic factors.

Examples of some cross-cutting areas for research are:

  • Ethnographic studies and other areas of social science, particularly to address health systems, availability of resources, preventive or screening practices, and appropriate interventions within a given society or group;
  • Gender and socio-cultural and economic factors in the etiology, prevention and treatment of the disorders to be addressed;
  • Sex differences at all levels of brain and nervous system function and disorders;
  • Natural history of common neurological diseases/disorders and the influence of socio-cultural or other environmental variables that impact upon this course and how to use this knowledge for treatment and intervention;
  • Factors associated with aging affecting cognitive, emotional and physical health and survival in older persons along with interventions and treatments;
  • Co-occurring risk factors or conditions, especially common in the LMIC or region (e.g. neuro-toxic or traumatic insult plus infectious disease and/or malnutrition);
  • Mechanisms (e.g. neurotoxic, epigenetic) underlying genetic, physiological, environmental, social and economic factors and interactions that affect brain function or development and result in behavioral outcomes (e.g., expression of cognitive impairment, coping, adaptation, response to intervention); and
  • Epidemiology: 1)  Descriptive epidemiology to describe and define the problem in the countries in question by assessing the needs and determining the magnitude of factors involved in the problem to be addressed (e.g., research on trends in incidence, prevalence or mortality; distribution of disease; determination of population at risk; determination of case definition/disease classification). 2) Analytical epidemiology to identify potential etiological factors in the populations of interest, including factors responsible for predispositions to the neurological consequences of various infection and/or neurotoxins (e.g., identification of risk factors for neurological consequences of disease onset or progression; classification and measurement of exposure; magnitude and distribution of known risk factors).

Types of research relevant to this announcement include basic research and epidemiology, as well as translational research, research on diagnostics, early interventions, clinical treatment, prevention, and health services that are culturally appropriate, feasible, and acceptable for implementation within the LMIC. This FOA encourages development of multidisciplinary and interdisciplinary research and the capacity in the LMIC to conduct such research, relevant to the research question. Expertise may involve, but is not limited to, fields such as genetics/epigenetics, epidemiology, neurology, cognitive neuroscience, developmental neurobiology, neuro-toxicology, neuro-endocrinology, pharmacology, psychiatry, neuro-immunology, neuro-virology, neurosurgery, neuro-rehabilitation and biotechnology (e.g., for development of diagnostic tools and treatments), as well as the behavioral and social sciences including health economics, health services and implementation science.

For More Information: http://grants.nih.gov/grants/guide/pa-files/PAR-14-332.html 

National Brain Tumor Foundation Translational Research Grant Award

National Brain Tumor Foundation Translational Research Grant Award

This $15,000 grant is awarded to the best translational research proposal on brain tumors. Proposals that bring novel laboratory research findings to clinical trial are preferred. Primary investigators must be practicing neurosurgeons within the first six years of their career.

Sponsorbrain_tumor_facts_image

National Brain Tumor Foundation

Grant Amount

$15,000.00

Number of Awards

One per year

Contact Name

Dr Michael McDermott

Award/Grant Category

Neurooncology

Phone

(415) 502-3744

Fax

(415) 476-9701

Email

BRAIN Initiative: Technology Sharing and Propagation (R03)

RFA-MH-16-725brain
BRAIN Initiative: Technology Sharing and Propagation (R03)
Department of Health and Human Services
National Institutes of Health

Section I. Funding Opportunity Description

Background

The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) InitiativeSM is aimed at revolutionizing our understanding of the human brain. By accelerating the development and application of innovative technologies, researchers will be able to produce a new dynamic picture of the brain that, for the first time, shows how individual cells and complex neural circuits interact in both time and space. It is expected that the application of these new tools and technologies will ultimately lead to new ways to treat, cure, and even prevent brain disorders.

NIH is one of several federal agencies involved in the BRAIN Initiative. Planning for the NIH component of the BRAIN Initiative is guided by the long-term scientific plan, “BRAIN 2025: A Scientific Vision,” which details seven high-priority research areas and calls for a sustained federal commitment of $4.5 billion over 12 years. This FOA and other BRAIN Initiative FOAs are based on careful consideration by the NIH of the recommendations of the BRAIN 2025 Report, and input from the NIH BRAIN Multi-Council Working Group (MCWG, Roster).  Information about MCWG meetings is available at http://www.braininitiative.nih.gov/index.htm.

In addition to the national BRAIN Initiative, the NIH continues to have a substantial annual investment in neuroscience research. The Institutes and Centers contributing to the NIH BRAIN Initiative support those research efforts through applications received via parent announcements as well as through specific FOAs. Potential applicants to this FOA are strongly encouraged to contact the Scientific/Research Contact if they have any questions about the best FOA for their research.

To promote progress in development of new technologies as well as in theory and data analysis, the BRAIN Initiative encourages collaborations between neurobiologists and researchers with expertise in statistics, physics, mathematics, engineering, and computer science, and NIH welcomes applications from investigators in these disciplines.

Research Objectives

This FOA seeks applications from investigators who can identify new technologies which, if introduced into their laboratory, will enable or promote new research activities that further the aims of the BRAIN initiative as described in the BRAIN 2025 Report.  Injection of these new technologies, whether experimental, theoretical or data analytical, into the applicant’s research program must newly enable experimentation in areas that are relevant to the NIH BRAIN Initiative.  Projects that are successful will result in a publication or other concrete deliverable that will allow the awardee to apply that technology or method in future research, and thus enhance research infrastructure.  This FOA is meant to support work on a particular research project that will illustrate that the technology has been mastered by the receiving laboratory.

NIH also supports dissemination activities between tool developers and the research community in other ways such as the dissemination activities of the BD2K Centers, the collaboration, service, and dissemination activities of the Biomedical Technology Research Resources and various NIH Career Development Awards.  This funding opportunity is distinct in its focus on the dissemination of tools related to the goals of the BRAIN Initiative.

The primary intent of this FOA is to inject technology into a particular laboratory that does not have experience with that technology, with the potential for sustained enhancement of the research conducted by that laboratory.  In some cases, effort may be needed by the developer of the technology to fit the needs of the recipient laboratory.  Such collaborations are welcome since a major purpose of the BRAIN Initiative is to support the development of new tools.  Although the new technology is transferred to a single research group, subsequent dissemination to other groups, performing research related to the aims of the BRAIN initiative, is welcomed.  While it is not required that the awardee have plans to re-distribute their newly gained expertise, groups with the intent and capability to more broadly disseminate their new expertise should briefly describe their plans.

Examples of supported activities include, but are not limited to:

  • Sending a faculty member, graduate student, postdoctoral fellow or technical staff to a company or academic laboratory that has developed a new technology, to collaborate on applying the technology to a problem of interest to the BRAIN initiative.
  • Bringing a member of a company or academic laboratory with a new technology to a research laboratory to establish or train members of the awardee laboratory, in applying the new tool in the context of a specific research project.
  • Establishing a collaboration whereby experts in theory, modeling, computer science, or statistics (TMCS) can introduce newly developed data analytics into the research program of the recipient laboratory. Such collaborations are likely to be most valuable early in the design of an experiment.  As with the tool development examples, the TMCS expert could either host a member of the academic laboratory or could visit that laboratory to disseminate expertise.

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-MH-16-725
Funding Opportunity Title: BRAIN Initiative: Technology Sharing and Propagation (R03)
Opportunity Category: Discretionary
Funding Instrument Type: Grant
Category of Funding Activity: Education
Health
Income Security and Social Services
Category Explanation:
Expected Number of Awards: 10
CFDA Number(s): 93.173 — Research Related to Deafness and Communication Disorders
93.213 — Research and Training in Complementary and Integrative Health
93.242 — Mental Health Research Grants
93.273 — Alcohol Research Programs
93.279 — Drug Abuse and Addiction Research Programs
93.286 — Discovery and Applied Research for Technological Innovations to Improve Human Health
93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders
93.865 — Child Health and Human Development Extramural Research
93.866 — Aging Research
93.867 — Vision Research
Cost Sharing or Matching Requirement: No

Posted Date:Aug 24, 2015

Creation Date:Aug 24, 2015

Original Closing Date for Applications:Jan 6, 2016

  Current Closing Date for Applications:Jan 6, 2016  

Archive Date:Feb 6, 2016

Estimated Total Program Funding:$1,000,000

Award Ceiling:$100,000

Award Floor:

Eligibility

Eligible Applicants:
Special district governments
City or township governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
State governments
Independent school districts
Public housing authorities/Indian housing authorities
Small businesses
County governments
Native American tribal governments (Federally recognized)
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Private institutions of higher education
Public and State controlled institutions of higher education
For profit organizations other than small businesses
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative Funding Opportunity Announcement (FOA) is to encourage the transfer of new technologies and new data analysis techniques into a research laboratory. One of the key goals of the BRAIN Initiative is to develop new technologies to improve our understanding of the brain. In order for those technologies to be useful, they need to be broadly disseminated beyond the laboratory or company where they originated. This FOA promotes this goal by providing funds to enable the incorporation of new technologies or data analysis techniques into research programs that further the aims of the BRAIN initiative.
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-16-725.html