Inclusion of Mobile/e-Consents for Alzheimer’s Disease Research (Admin Supp)

PA-16-259
Inclusion of Mobile/e-Consents for Alzheimer’s Disease Research (Admin Supp)
Department of Health and Human Services
National Institutes of Healthalzheimer's disease

Administrative Supplement

Additional funds may be awarded as supplements to parent awards using the following Activity Code(s):

Administrative supplement requests must be submitted on paper for the following activity codes:

P30 Center Core Grants

P50 Specialized Center

U19 Research Program – Cooperative Agreements

U2C Resource-Related Research Multi-Component Projects & Centers

Cooperative Agreements

U54 Specialized Center- Cooperative Agreements

Administrative supplement requests may be submitted electronically for the following activity codes:

R01 Research Project Grant
R34 Clinical Trial Planning Grant Program
R41 Small Business Technology Transfer (STTR) Grant – Phase I only
R41/R42 Small Business Technology Transfer (STTR) Grant – Phase I, Phase II, and Fast-Track
R41/R42 Small Business Technology Transfer (STTR) Grant – Phase I and Phase II
R42 Small Business Technology Transfer (STTR) Grant – Phase II only
R43 Small Business Innovation Research (SBIR) Grant – Phase I only
R43/R44 Small Business Innovation Research (SBIR) Grant – Phase I, Phase II, and Fast-Track
R43/R44 Small Business Innovation Research (SBIR) Grant – Phase I and Phase II
R44 Small Business Innovation Research (SBIR) Grant – Phase II only

U01 Research Project – Cooperative Agreements

U24 Resource-Related Research Projects – Cooperative Agreements U44 Small Business Innovation Research (SBIR) Cooperative Agreements – Phase II

General Information

Document Type: Grants Notice
Funding Opportunity Number: PA-16-259
Funding Opportunity Title: Inclusion of Mobile/e-Consents for Alzheimer’s Disease Research (Admin Supp)
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Grant
Category of Funding Activity: Health
Category Explanation:
Expected Number of Awards: 2
CFDA Number(s): 93.866 — Aging Research
Cost Sharing or Matching Requirement: No
Posted Date: May 16, 2016
Last Updated Date: May 16, 2016
Original Closing Date for Applications: Aug 15, 2016  
Current Closing Date for Applications: Aug 15, 2016  
Archive Date: Sep 15, 2016
Estimated Total Program Funding: $300,000
Award Ceiling: $100,000
Award Floor:

Eligibility

Eligible Applicants:
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
County governments
Public and State controlled institutions of higher education
Public housing authorities/Indian housing authorities
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Native American tribal organizations (other than Federally recognized tribal governments)
City or township governments
Small businesses
Independent school districts
For profit organizations other than small businesses
State governments
Native American tribal governments (Federally recognized)
Private institutions of higher education
Special district governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Additional Information

Agency Name: National Institutes of Health
Description: The National Institute on Aging (NIA) announces the availability of administrative supplements to support the development and implementation of innovative strategies to utilize mobile electronic consents in Alzheimer’s Disease clinical research.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PA-16-259.html
Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV
If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

From Association to Function in the Alzheimers Disease Post Genomics Era (R01)

RFA-AG-17-010
From Association to Function in the Alzheimers Disease Post Genomics Era (R01)
Department of Health and Human Services
National Institutes of Health

PET_AD-PUBLIC

Research Objectives

Currently, the AD research community is facing many different challenges between identifying critical AD risk gene variants and elucidating the potential biological and pathological functions of these variants in the initiation and propagation of AD. Protein activity and function are the end game mediators of the effects of AD risk gene variants.  For example, gene variants may affect protein-DNA or –RNA interactions, protein translation, or protein complex formation that may be missed by “omics” expression approaches.  As a consequence, it is critical to identify and develop more effective ways to rapidly screen variants for impact on potential biological functions prior to any in-depth mechanistic studies.   In addition, this initiative also encourages investigators to create a more integrated and effective platform to identify protein-protein interactions, protein complexes and their regulation caused by AD genetic variants.  To build on the large amount of genetics and “omics” datasets generated with support from NIA supported GWAS, Alzheimer’s Disease Sequencing Project (ADSP) and other projects, this initiative strongly encourages collaborative and multi-institutional research applications designed to quickly reduce the complexity of GWAS, DNA sequencing and “omics” datasets, either computationally or experimentally; and to provide a robust pipeline to validate the function at the protein level of candidate variants using in vitro and in vivo model systems.

Areas of research interest include, but are not limited to:

Implementation of Proteome-Wide Analysis of disease-associated SNPs (PWAS) on non-protein coding regions to identify allele-specific transcription factor binding and alteration of promoter or enhancer activity in AD. The advantage of using unbiased PWAS for AD research is that it will allow one to link genomic studies to protein function without prior information.

Comprehensive and deep proteomics analyses to understand the impact of GWAS genetic variants; and identify key molecular signatures and networks in modulating the early pathogenesis of AD.  Any protein expression profiling analysis solely to generate a large dataset without any functional validation will not be considered responsive.

Test the function of coding genetic variants and to determine the roles of genetic variants or post-translational modifications, cell signaling and protein homeostasis in sporadic AD.  Functional analysis can range from biochemical assays to imaging of cells or tissues in various in vitro and in vivo models of sporadic AD.

Implementation of local and web-based in silico model systems to predict the three dimensional structure and function of mutant vs wild type AD risk proteins, particularly if the mutations are located within the protein coding sequence.  However, it is expected that any variant function identified by in silico model analysis will need to be confirmed by a complementary in vitro biochemical, cell or animal-based assay.

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-AG-17-010
Funding Opportunity Title: From Association to Function in the Alzheimers Disease Post Genomics Era (R01)
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Grant
Category of Funding Activity: Health
Category Explanation:
Expected Number of Awards:
CFDA Number(s): 93.866 — Aging Research
Cost Sharing or Matching Requirement: No
Posted Date: May 11, 2016
Last Updated Date: May 11, 2016
Original Closing Date for Applications: Sep 27, 2016  
Current Closing Date for Applications: Sep 27, 2016  
Archive Date: Oct 28, 2016
Estimated Total Program Funding: $4,000,000
Award Ceiling: $350,000

Eligibility

Eligible Applicants:
County governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
City or township governments
Private institutions of higher education
State governments
For profit organizations other than small businesses
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Public and State controlled institutions of higher education
Public housing authorities/Indian housing authorities
Small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
Special district governments
Native American tribal governments (Federally recognized)
Independent school districts
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: This Funding Opportunity Announcement (FOA) solicits innovative and collaborative research focused on understanding the structure and function of proteins or protein complexes regulated by different AD genetic variants that have been identified to be associated with the sporadic and late onset Alzheimers disease (AD). Specifically, NIA is interested in identifying and developing more effective and integrated platforms to screen protein functions, protein-protein interaction, protein complexes and their regulation by AD genetic variants prior to any in-depth mechanistic studies. The program encourages collaborative research projects that will translate initial GWAS discovery into functional and phenotypical insights and ultimately lead to understand the complex biology of AD.
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-17-010.html
Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV
If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster