Data Integration and Analysis Tools: Accessible Resources for Integration and Analysis of Carbohydrate and Glycoconjugate Data in the Context of Comparable Gene, Protein, and Lipid Data (U01)

RFA-RM-16-021
Data Integration and Analysis Tools: Accessible Resources for Integration and Analysis of Carbohydrate and Glycoconjugate Data in the Context of Comparable Gene, Protein, and Lipid Data (U01)
Department of Health and Human Services
National Institutes of Health

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Research Objectives and Scope

The analysis and integration of carbohydrate and glycoconjugate data is a complex challenge. Present computational and informatics technologies for carbohydrate analysis are decades behind those developed for nucleic acids and proteins. Like other aspects of glycobiology, progress in glycoinformatics is sporadic and fragmented. The resulting tools are primitive, and poorly integrated, and adoption by non-specialists has been slow. Certain glycoinformatics tools, such as glycan structure databases, have been developed. These databases, however, are limited and balkanized, and are not matched with tools for interrogating the databases in meaningful ways. They are also not well-integrated with databases for proteins or genomic information. Other classes of glycoinformatics tools are in their infancy, or entirely lacking. Examples include algorithms for spectral interpretation to support glycoconjugate structure determination, or interpretation of glycan array binding data.

Recent community-led efforts to arrive at standardization of glycan nomenclature as expressed in databases, interoperability of databases, and reporting of experimental metadata have been promising. Two important features of these recent efforts are: (1) they have been inclusive, community-driven projects, and (2) they have focused on preserving the utility of the tools already created.  Efforts to bring glycoinformatics up to the current state of the art available for the other classes of biological macromolecules must be grounded in a clearly articulated vision for addressing the significant challenges confronting the field, and facilitate participation of many independent research groups. The project should create an environment that enables current and future software developers to join this effort with a clear understanding of the framework within which their contributions will be most effective.

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-RM-16-021
Funding Opportunity Title: Data Integration and Analysis Tools: Accessible Resources for Integration and Analysis of Carbohydrate and Glycoconjugate Data in the Context of Comparable Gene, Protein, and Lipid Data (U01)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Cooperative Agreement
Category of Funding Activity: Health
Category Explanation:  
Expected Number of Awards: 1
CFDA Number(s): 93.310 — Trans-NIH Research Support
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Sep 16, 2016
Last Updated Date: Sep 16, 2016
Original Closing Date for Applications: Nov 28, 2016  
Current Closing Date for Applications: Nov 28, 2016  
Archive Date: Dec 29, 2016
Estimated Total Program Funding: $2,000,000
Award Ceiling: $1,500,000
Award Floor:

Eligibility

Eligible Applicants: City or township governments
Special district governments
Public housing authorities/Indian housing authorities
Native American tribal governments (Federally recognized)
Native American tribal organizations (other than Federally recognized tribal governments)
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
For profit organizations other than small businesses
State governments
Independent school districts
Public and State controlled institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Small businesses
County governments
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name: National Institutes of Health
Description: The Common Fund Program – Accelerating Translation of Glycoscience: Integration and Accessibility – aims to develop accessible and affordable new tools and technologies for studying carbohydrates that will allow biomedical researchers to significantly advance our understanding of the roles of these complex molecules in health and disease. This program will enable investigators who might not otherwise conduct research in the glycosciences, to undertake the study of carbohydrate structure and function.
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-16-021.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

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