Limited Competition for the Continuation of the Hepatitis B Research Network Clinical Centers (U01)

Limited Competition for the Continuation of the Hepatitis B Research Network Clinical Centers (U01)
Department of Health and Human Services
National Institutes of Healthhepatitis-b

Section I. Funding Opportunity Description

In prior funding cycles, the HBRN has developed and initiated the following protocols: an Adult and a Pediatric Cohort studies; the Adult Immune Active study; an Adult and a Pediatric Immune Tolerant studies.  Additional ancillary studies have been developed and implemented that focus on specific aspects of various clinical scenarios, approaches to assessment, or complications that are associated with hepatitis B.  In addition to the clinical studies in progress noted above, the HBRN has developed a biospecimen repository consisting of over 340,600 adult and 10,700 pediatric plasma and sera samples; and 1372 adult and 182 pediatric DNA specimens; along with detailed clinical database.

The HBRN is currently composed of 15 adult and 7 pediatric clinical sites throughout North America and a Data Coordination Center through 10 individual U01 Cooperative Agreements.

The HBRN Clinical Centers, which will be supported through this FOA, are  primarily charged with completing and analyzing the various clinical studies currently underway and for the future, to consider novel treatment trials for chronic hepatitis B and delta hepatitis; and to exploit translational research opportunities with the vast collection of biospecimens in the repository .

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-DK-16-512
Funding Opportunity Title: Limited Competition for the Continuation of the Hepatitis B Research Network Clinical Centers (U01)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Cooperative Agreement
Category of Funding Activity: Food and Nutrition
Category Explanation:  
Expected Number of Awards:  
CFDA Number(s): 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Aug 18, 2016
Last Updated Date: Aug 18, 2016
Original Closing Date for Applications: Dec 19, 2016  
Current Closing Date for Applications: Dec 19, 2016  
Archive Date: Jan 19, 2017
Estimated Total Program Funding: $7,000,000
Award Ceiling:  
Award Floor:


Eligible Applicants: Others (see text field entitled “Additional Information on Eligibility” for clarification)
Additional Information on Eligibility: Other Eligible Applicants include the following: Faith-based or Community-based Organizations; Only the current HBRN awardees are eligible to apply to this FOA. Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. See FOA for Eligibility Details

Additional Information

Agency Name: National Institutes of Health
Description: The purpose of this Funding Opportunity Announcement (FOA) is to continue the Hepatitis B Research Network Clinical Centers with a focus on the promotion of translational research on hepatitis B focusing upon elucidating the pathogenesis and natural history and developing means of treatment and control.
Link to Additional Information:
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster


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