Identification of Mechanisms Mediating the Effects of Sleep on Diabetes-Related Metabolism in Humans (R01)
Department of Health and Human Services
National Institutes of Health
The purpose of this FOA is to invite applications that investigate the mechanisms mediating the interactions between sleep and diabetes-related metabolism using deep metabolic phenotyping approaches in healthy human populations and those with metabolic and/or sleep disorders.
Large, epidemiological studies support an association between disrupted sleep [sleep deprivation, sleep fragmentation, short sleep, and obstructive sleep apnea (OSA)] and dysregulated metabolism, specifically increased body weight and/or glucose intolerance. Small studies conducted primarily in healthy control subjects also indicate that laboratory-induced sleep deprivation impairs insulin sensitivity and may have effects on other metabolic indices that impact insulin sensitivity and glucose tolerance including circulating inflammatory markers, lipid metabolism, autonomic nervous system activity and food intake. Small studies conducted in clinical populations such as individuals with OSA, also show a relationship between OSA and impaired glucose tolerance or decreased insulin sensitivity relative to matched controls. However, while small studies show treatment of OSA generally seems to improve insulin sensitivity, there are minimal effects on glucose tolerance.
The mechanisms mediating impairment of glucose metabolism and insulin sensitivity by sleep disruption are not known. Current animal models of sleep disruption often do not replicate the human sleep disorders and thus limit translation of findings from rodents into humans. To date, human studies examining the effects of sleep disruption on diabetes related metabolism have not included in-depth metabolic phenotyping that would contribute to elucidating potential mediators or to identifying the tissue site (or sites) associated with disrupted metabolism. Furthermore, the majority of studies on human sleep and glucose metabolism have been conducted in healthy subjects whose sleep has been disrupted by various interventions in a controlled laboratory setting. Few studies have attempted to treat sleep disorders in populations with metabolic or sleep disorders and demonstrate improvements in glucose homeostasis or diabetes-related metabolism. Identifying a population with a known metabolic or sleep disorder and being able to demonstrate that a therapeutic sleep intervention can ameliorate abnormalities in glucose or diabetes-related metabolism would have important clinical implications.
This FOA invites applications which propose in-depth metabolic phenotyping in carefully selected clinical populations to determine how changes in sleep (improvements or disruptions) influence diabetes-related metabolism. Applications should systematically test a physiological model with the goal of elucidating possible mediators of the reported effects of sleep on glucose metabolism. Applications that propose therapeutic interventions to improve sleep and determine the consequences on diabetes-related metabolism must have preliminary data demonstrating that the proposed method for improving sleep is actually efficacious.
|Posted Date:||Aug 17, 2016|
|Last Updated Date:||Aug 17, 2016|
|Original Closing Date for Applications:||Oct 11, 2017|
|Current Closing Date for Applications:||Oct 11, 2017|
|Archive Date:||Nov 11, 2017|
|Estimated Total Program Funding:|
|Eligible Applicants:||Small businesses
Public and State controlled institutions of higher education
Public housing authorities/Indian housing authorities
City or township governments
For profit organizations other than small businesses
Independent school districts
Native American tribal governments (Federally recognized)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
Special district governments
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
|Additional Information on Eligibility:||Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.|
|Agency Name:||National Institutes of Health|
|Description:||The purpose of this Funding Opportunity Announcement is to invite applications that investigate the mechanisms mediating the interactions between sleep and diabetes-related metabolism using deep metabolic phenotyping approaches in healthy human populations and those with metabolic and/or sleep disorders.|
|Link to Additional Information:||http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-16-005.html|
|Grantor Contact Information:||If you have difficulty accessing the full announcement electronically, please contact:
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