ADVANCE: Increasing the Participation and Advancement of Women in Academic Science and Engineering Careers

16-594
ADVANCE: Increasing the Participation and Advancement of Women in Academic Science and Engineering Careers
National Science FoundationWISE

General Information

Document Type: Grants Notice
Funding Opportunity Number: 16-594
Funding Opportunity Title: ADVANCE: Increasing the Participation and Advancement of Women in Academic Science and Engineering Careers
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Grant
Category of Funding Activity: Science and Technology and other Research and Development
Category Explanation:  
Expected Number of Awards: 26
CFDA Number(s): 47.041 — Engineering Grants
47.049 — Mathematical and Physical Sciences
47.050 — Geosciences
47.070 — Computer and Information Science and Engineering
47.074 — Biological Sciences
47.075 — Social, Behavioral, and Economic Sciences
47.076 — Education and Human Resources
47.079 — Office of International Science and Engineering
47.083 — Office of Integrative Activities
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Aug 27, 2016
Last Updated Date: Aug 27, 2016
Original Closing Date for Applications: Jan 11, 2017  Adaptation Letter of Intent; Adaptation full proposal; Partnerships Letter of Intent; Partnerships Full Proposal; Institutional Transformation Preliminary Proposal; Institutional Transformation full proposal
Current Closing Date for Applications: Jan 11, 2017  Adaptation Letter of Intent; Adaptation full proposal; Partnerships Letter of Intent; Partnerships Full Proposal; Institutional Transformation Preliminary Proposal; Institutional Transformation full proposal
Archive Date: Feb 18, 2022
Estimated Total Program Funding: $22,200,000
Award Ceiling: $3,000,000
Award Floor: $1,000,000

 
Additional Information

Agency Name: National Science Foundation
Description: Despite significant increases in the proportion of women pursuing science, technology, engineering, and mathematics (STEM) doctoral degrees, women are significantly underrepresented as faculty, particularly in upper ranks, and in academic administrative positions, in almost all STEM fields.  The problems of recruitment, retention, and advancement that are the causes of this underrepresentation vary by discipline and across groups of women faculty (e.g., by race/ethnicity, disability status, sexual orientation, foreign-born and foreign-trained status, and faculty appointment type).  The ADVANCE program is designed to foster gender equity through a focus on the identification and elimination of organizational barriers that impede the full participation and advancement of all women faculty in academic institutions.  Organizational barriers that inhibit equity may exist in areas such as policy, practice, culture, and organizational climate.  For example, practices in academic departments that result in the inequitable allocation of service or teaching assignments may impede research productivity, delay advancement and create a culture of differential treatment and rewards.  Policies and procedures that do not mitigate implicit bias in hiring, tenure, and promotion decisions could mean that women and underrepresented minorities are evaluated less favorably, perpetuating their underrepresentation and contributing to a climate that is not inclusive.     The goals of the ADVANCE program are (1) to develop systemic approaches to increase the representation and advancement of women in academic STEM, [1] careers; (2) to develop innovative and sustainable ways to promote gender equity that involve both men and women in the STEM academic workforce; and (3) to contribute to the research knowledge base on gender equity and the intersection of gender and other identities in STEM academic careers.  The ADVANCE program contributes to the development of a more diverse science and engineering workforce because of the focus on equity for STEM academic faculty who are educating, training, and mentoring undergraduate and graduate students and postdoctoral scholars.  There are three program tracks.  All projects are expected to build on prior ADVANCE work and gender equity research and literature to broaden the implementation of organizational and systemic strategies to foster gender equity in STEM academic careers.  All ADVANCE proposals are expected to recognize that gender does not exist in isolation from other characteristics, such as race/ethnicity, disability status, sexual orientation, foreign-born and foreign-trained status, faculty appointment type, etc., and should offer strategies to promote gender equity for all faculty: The Institutional Transformation (IT) track supports the development of innovative organizational change strategies to produce comprehensive change within one non-profit two-year or four-year academic institution across all STEM disciplines.  IT projects are also expected to contribute new research on gender equity in STEM academics.  Projects that do not propose innovative strategies may be more appropriate for the Adaptation track.

The Adaptation track supports the adaptation and implementation of evidence-based organizational change strategies, ideally from among those developed and implemented by ADVANCE projects.  Adaptation awards may support the adaptation and implementation of proven organizational change strategies within a non-profit two-year or four-year academic institution that has not had an ADVANCE IT award.  Adaptation awards may also be made to a STEM organization to implement systemic change strategies focused across all STEM disciplines, several STEM disciplines, or within one STEM discipline.  The Partnership track will support partnerships of two or more non-profit academic institutions and/or STEM organizations to increase gender equity in STEM academics.  Projects should have national or regional impact and result in systemic change within one STEM discipline, several STEM disciplines, or all STEM disciplines.  Partnering STEM organizations can include any entity eligible for NSF support.  Partners may include professional societies, industry, non-profit organizations, publishers, policy and research entities, state systems of higher education, higher education organizations, as well as institutions of higher education.  Partnership proposals must include a final year focused on sustainability and/or scale-up, communication, and evaluation. For all proposals, ADVANCE is interested in supporting a range of non-profit academic institution types including: community colleges, primarily undergraduate institutions, minority-serving institutions (e.g. Tribal Colleges and Universities, Historically Black Colleges and Universities, Hispanic-Serving Institutions, Native Hawaiian Serving Institutions, Alaska Native Institutions, Predominantly Black Institutions and Non-tribal, Native American Serving Institutions), women’s colleges, institutions primarily serving persons with disabilities, and master’s and doctoral level institutions. ADVANCE does not provide fellowships, research grants, or travel grants to individual students, postdocs, or faculty.  Undergraduate STEM opportunities can be found at <a href= http://stemundergrads.science.gov and graduate STEM opportunities at = http://stemgradstudents.science.gov

All STEM fields supported by NSF are included in the ADVANCE program.  STEM includes the learning, social, behavioral, and economic sciences.  The program does not include clinical science faculty. </div> </div>

Link to Additional Information: NSF Publication 16-594
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NSF grants.gov support grantsgovsupport@nsf.gov

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NLM Grants for Scholarly Works in Biomedicine and Health (G13)

PAR-16-417
NLM Grants for Scholarly Works in Biomedicine and Health (G13)
Department of Health and Human Services
National Institutes of Healthbiomedicine

Section I. Funding Opportunity Description

The National Library of Medicine (NLM) awards Grants for Scholarly Works in Biomedicine and Health for the preparation of book-length manuscripts and other works of academic and/or public health policy value to U.S. health professionals, public health officials, biomedical researchers, and historians of the health sciences. Grants are awarded for major critical reviews, state-of-the-art summaries, historical studies, and other useful organizations of knowledge in clinical medicine, public health, biomedical research, and the informatics/information sciences relating to them. The work of academic and/or public health policy value may be prepared for publication in print or electronic media, or both.

Scholars in biomedical fields face competing demands for their time, including requirements for clinical care services, grant-related research and administrative duties. Scholarly work draws upon original sources that may reside in archives, databases, libraries or human experts around the world, in many different languages and formats. The work of scholarship – discovery, thoughtful analysis, synthesis and lucid presentation of findings from such materials – requires protected time and support for incidental costs, including materials, staff assistance, and travel. The NLM Grant for Scholarly Works in Biomedicine and Health is intended to help defray such expenses.

NLM Grants for Scholarly Works can be used to support several types of projects of academic and/or public health policy value, including but not limited to:

  • Works focusing on the history or philosophy of medicine, public health and the life sciences, the development of medical research and health services, bioethics, and studies on the interrelationship of medicine and society
  • Works focusing on the history or philosophy of biomedical informatics, computational biology, health information sciences, health communications, or health sciences librarianship
  • Analytical and comprehensive critical reviews which identify the present status of research and practice in various health-related fields, addressing advances which have been made, problems requiring examination, and emerging trends

General Information

Document Type: Grants Notice
Funding Opportunity Number: PAR-16-417
Funding Opportunity Title: NLM Grants for Scholarly Works in Biomedicine and Health (G13)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Grant
Category of Funding Activity: Education
Health
Category Explanation:  
Expected Number of Awards:  
CFDA Number(s): 93.879 — Medical Library Assistance
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Aug 26, 2016
Last Updated Date: Aug 26, 2016
Original Closing Date for Applications: Feb 23, 2018  
Current Closing Date for Applications: Feb 23, 2018  
Archive Date: Mar 26, 2018
Estimated Total Program Funding:  
Award Ceiling: $50,000
Award Floor:  

Eligibility

Eligible Applicants: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Public housing authorities/Indian housing authorities
Others (see text field entitled “Additional Information on Eligibility” for clarification)
City or township governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Special district governments
Public and State controlled institutions of higher education
Native American tribal governments (Federally recognized)
Small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
County governments
Independent school districts
Private institutions of higher education
For profit organizations other than small businesses
State governments
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Additional Information

Agency Name: National Institutes of Health
Description: NLM Grants for Scholarly Works in Biomedicine and Health are awarded for the preparation of book-length manuscripts and other works of academic and/or public health policy value to U.S. health professionals, public health officials, biomedical researchers and historians of the health sciences.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PAR-16-417.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

NCI Small Grants Program for Cancer Research (NCI Omnibus R03)

PAR-14-007
NCI Small Grants Program for Cancer Research (NCI Omnibus R03)
Department of Health and Human Services
National Institutes of Healthall-of-us-v-cancer

Section I. Funding Opportunity Description

This funding opportunity announcement (FOA), issued by the National Cancer Institute (NCI) of the National Institutes of Health (NIH), supports discrete, well-defined projects in any area of cancer research using the NIH R03 small grant mechanism.

The NIH R03 small grant mechanism supports discrete, well-defined projects that realistically can be completed in 2 years and that require limited levels of funding. Examples of the types of projects that the R03 grant mechanism include, but are not limited to, the following:

  • Pilot or feasibility studies;
  • Secondary analysis of existing data;
  • Small, self-contained research projects;
  • Development of research methodology; and
  • Development of new research technology.
Specific Research Objectives

All areas of cancer research relevant to the mission of the NCI are appropriate for projects submitted in response to this FOA (for a list of extramural research funding programs at the NCI, go to http://www.cancer.gov/researchandfunding/extramural). Projects proposed in response to this FOA may involve basic, translational, clinical, and/or population research related to cancer. Examples of relevant areas include but are not limited to studies of: cancer biology; cancer control; cancer diagnosis; cancer disparities; cancer prevention; and cancer treatment.

General Information

Document Type: Grants Notice
Funding Opportunity Number: PAR-14-007
Funding Opportunity Title: NCI Small Grants Program for Cancer Research (NCI Omnibus R03)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Grant
Category of Funding Activity: Education
Health
Category Explanation:  
Expected Number of Awards:  
CFDA Number(s): 93.393 — Cancer Cause and Prevention Research
93.394 — Cancer Detection and Diagnosis Research
93.395 — Cancer Treatment Research
93.396 — Cancer Biology Research
93.399 — Cancer Control
Cost Sharing or Matching Requirement: No
Version: Synopsis 2
Posted Date: Nov 21, 2013
Last Updated Date: Aug 26, 2016
Original Closing Date for Applications: Jan 05, 2017  
Current Closing Date for Applications: Aug 26, 2016  
Archive Date: Sep 26, 2016
Estimated Total Program Funding:  
Award Ceiling: $50,000
Award Floor:  

Eligibility

Eligible Applicants: Native American tribal organizations (other than Federally recognized tribal governments)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
County governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Small businesses
For profit organizations other than small businesses
State governments
Public housing authorities/Indian housing authorities
Special district governments
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Independent school districts
Public and State controlled institutions of higher education
Private institutions of higher education
City or township governments
Native American tribal governments (Federally recognized)
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name: National Institutes of Health
Description: This funding opportunity announcement (FOA), issued by the National Cancer Institute (NCI), of the National Institutes of Health (NIH) supports small research projects on cancer that can be carried out in a short period of time with limited resources. The R03 grant mechanism supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PAR-14-007.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

NSF: Ecology and Evolution of Infectious Diseases

Ecology and Evolution of Infectious Diseases
National Science Foundationinfectiousdisease-MOOC

SYNOPSIS

The Ecology and Evolution of Infectious Diseases program supports research on the ecological, evolutionary, and socio-ecological principles and processes that influence the transmission dynamics of infectious diseases. The central theme of submitted projects must be quantitative or computational understanding of pathogen transmission dynamics. The intent is discovery of principles of infectious disease transmission and testing mathematical or computational models that elucidate infectious disease systems. Projects should be broad, interdisciplinary efforts that go beyond the scope of typical studies. They should focus on the determinants and interactions of transmission among humans, non-human animals, and/or plants. This includes, for example, the spread of pathogens; the influence of environmental factors such as climate; the population dynamics and genetics of reservoir species or hosts; the cultural, social, behavioral, and economic dimensions of disease transmission. Research may be on zoonotic, environmentally-borne, vector-borne, or enteric diseases of either terrestrial or freshwater systems and organisms, including diseases of animals and plants, at any scale from specific pathogens to inclusive environmental systems. Proposals for research on disease systems of public health concern to developing countries are strongly encouraged, as are disease systems of concern in agricultural systems. Investigators are encouraged to develop the appropriate multidisciplinary team, including for example, modelers, bioinformaticians, genomics researchers, social scientists, economists, epidemiologists, entomologists, parasitologists, microbiologists, bacteriologists, virologists, pathologists or veterinarians, with the goal of integrating knowledge across disciplines to enhance our ability to predict and control infectious diseases.

Document Type: Grants Notice
Funding Opportunity Number: 16-592
Funding Opportunity Title: Ecology and Evolution of Infectious Diseases
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Grant
Category of Funding Activity: Science and Technology and other Research and Development
Category Explanation:  
Expected Number of Awards:  
CFDA Number(s): 10.310 — Agriculture and Food Research Initiative (AFRI)
47.074 — Biological Sciences
47.075 — Social, Behavioral, and Economic Sciences
93.856 — Microbiology and Infectious Diseases Research
93.859 — Biomedical Research and Research Training
93.989 — International Research and Research Training
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Aug 19, 2016
Last Updated Date: Aug 19, 2016
Original Closing Date for Applications: Nov 16, 2016  
Current Closing Date for Applications: Nov 16, 2016  
Archive Date: Dec 18, 2020
Estimated Total Program Funding: $13,500,000
Award Ceiling: $2,500,000
Award Floor: $1,000,000

Eligibility

Eligible Applicants: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility”
Additional Information on Eligibility:  

Additional Information

Agency Name: National Science Foundation
Description: The Ecology and Evolution of Infectious Diseases program supports research on the ecological, evolutionary, and socio-ecological principles and processes that influence the transmission dynamics of infectious diseases. The central theme of submitted projects must be quantitative or computational understanding of pathogen transmission dynamics. The intent is discovery of principles of infectious disease transmission and testing mathematical or computational models that elucidate infectious disease systems. Projects should be broad, interdisciplinary efforts that go beyond the scope of typical studies. They should focus on the determinants and interactions of transmission among humans, non-human animals, and/or plants. This includes, for example, the spread of pathogens; the influence of environmental factors such as climate; the population dynamics and genetics of reservoir species or hosts; the cultural, social, behavioral, and economic dimensions of disease transmission. Research may be on zoonotic, environmentally-borne, vector-borne, or enteric diseases of either terrestrial or freshwater systems and organisms, including diseases of animals and plants, at any scale from specific pathogens to inclusive environmental systems. Proposals for research on disease systems of public health concern to developing countries are strongly encouraged, as are disease systems of concern in agricultural systems. Investigators are encouraged to develop the appropriate multidisciplinary team, including for example, modelers, bioinformaticians, genomics researchers, social scientists, economists, epidemiologists, entomologists, parasitologists, microbiologists, bacteriologists, virologists, pathologists or veterinarians, with the goal of integrating knowledge across disciplines to enhance our ability to predict and control infectious diseases.
Link to Additional Information: NSF Publication 16-592
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NSF grants.gov support grantsgovsupport@nsf.gov

If you have any problems linking to this funding announcement, please contact us.

Limited Competition for the Continuation of the Hepatitis B Research Network Clinical Centers (U01)

RFA-DK-16-512
Limited Competition for the Continuation of the Hepatitis B Research Network Clinical Centers (U01)
Department of Health and Human Services
National Institutes of Healthhepatitis-b

Section I. Funding Opportunity Description

In prior funding cycles, the HBRN has developed and initiated the following protocols: an Adult and a Pediatric Cohort studies; the Adult Immune Active study; an Adult and a Pediatric Immune Tolerant studies.  Additional ancillary studies have been developed and implemented that focus on specific aspects of various clinical scenarios, approaches to assessment, or complications that are associated with hepatitis B.  In addition to the clinical studies in progress noted above, the HBRN has developed a biospecimen repository consisting of over 340,600 adult and 10,700 pediatric plasma and sera samples; and 1372 adult and 182 pediatric DNA specimens; along with detailed clinical database.

The HBRN is currently composed of 15 adult and 7 pediatric clinical sites throughout North America and a Data Coordination Center through 10 individual U01 Cooperative Agreements.

The HBRN Clinical Centers, which will be supported through this FOA, are  primarily charged with completing and analyzing the various clinical studies currently underway and for the future, to consider novel treatment trials for chronic hepatitis B and delta hepatitis; and to exploit translational research opportunities with the vast collection of biospecimens in the repository .

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-DK-16-512
Funding Opportunity Title: Limited Competition for the Continuation of the Hepatitis B Research Network Clinical Centers (U01)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Cooperative Agreement
Category of Funding Activity: Food and Nutrition
Health
Category Explanation:  
Expected Number of Awards:  
CFDA Number(s): 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Aug 18, 2016
Last Updated Date: Aug 18, 2016
Original Closing Date for Applications: Dec 19, 2016  
Current Closing Date for Applications: Dec 19, 2016  
Archive Date: Jan 19, 2017
Estimated Total Program Funding: $7,000,000
Award Ceiling:  
Award Floor:

Eligibility

Eligible Applicants: Others (see text field entitled “Additional Information on Eligibility” for clarification)
Additional Information on Eligibility: Other Eligible Applicants include the following: Faith-based or Community-based Organizations; Only the current HBRN awardees are eligible to apply to this FOA. Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. See FOA for Eligibility Details

Additional Information

Agency Name: National Institutes of Health
Description: The purpose of this Funding Opportunity Announcement (FOA) is to continue the Hepatitis B Research Network Clinical Centers with a focus on the promotion of translational research on hepatitis B focusing upon elucidating the pathogenesis and natural history and developing means of treatment and control.
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-16-512.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

Identification of Mechanisms Mediating the Effects of Sleep on Diabetes-Related Metabolism in Humans (R01)

RFA-DK-16-005
Identification of Mechanisms Mediating the Effects of Sleep on Diabetes-Related Metabolism in Humans (R01)
Department of Health and Human Services
National Institutes of Health

Section I. Funding Opportunity Description

The purpose of this FOA is to invite applications that investigate the mechanisms mediating the interactions between sleep and diabetes-related metabolism using deep metabolic phenotyping approaches in healthy human populations and those with metabolic and/or sleep disorders.diabetes

Large, epidemiological studies support an association between disrupted sleep [sleep deprivation, sleep fragmentation, short sleep, and obstructive sleep apnea (OSA)] and dysregulated metabolism, specifically increased body weight and/or glucose intolerance. Small studies conducted primarily in healthy control subjects also indicate that laboratory-induced sleep deprivation impairs insulin sensitivity and may have effects on other metabolic indices that impact insulin sensitivity and glucose tolerance including circulating inflammatory markers, lipid metabolism, autonomic nervous system activity and food intake.  Small studies conducted in clinical populations such as individuals with OSA, also show a relationship between OSA and impaired glucose tolerance or decreased insulin sensitivity relative to matched controls. However, while small studies show treatment of OSA generally seems to improve insulin sensitivity, there are minimal effects on glucose tolerance.

The mechanisms mediating impairment of glucose metabolism and insulin sensitivity by sleep disruption are not known. Current animal models of sleep disruption often do not replicate the human sleep disorders and thus limit translation of findings from rodents into humans. To date, human studies examining the effects of sleep disruption on diabetes related metabolism have not included in-depth metabolic phenotyping that would contribute to elucidating potential mediators or to identifying the tissue site (or sites) associated with disrupted metabolism. Furthermore, the majority of studies on human sleep and glucose metabolism have been conducted in healthy subjects whose sleep has been disrupted by various interventions in a controlled laboratory setting. Few studies have attempted to treat sleep disorders in populations with metabolic or sleep disorders and demonstrate improvements in glucose homeostasis or diabetes-related metabolism. Identifying a population with a known metabolic or sleep disorder and being able to demonstrate that a therapeutic sleep intervention can ameliorate abnormalities in glucose or diabetes-related metabolism would have important clinical implications.

This FOA invites applications which propose in-depth metabolic phenotyping in carefully selected clinical populations to determine how changes in sleep (improvements or disruptions) influence diabetes-related metabolism. Applications should systematically test a physiological model with the goal of elucidating possible mediators of the reported effects of sleep on glucose metabolism. Applications that propose therapeutic interventions to improve sleep and determine the consequences on diabetes-related metabolism must have preliminary data demonstrating that the proposed method for improving sleep is actually efficacious.

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-DK-16-005
Funding Opportunity Title: Identification of Mechanisms Mediating the Effects of Sleep on Diabetes-Related Metabolism in Humans (R01)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Grant
Category of Funding Activity: Food and Nutrition
Health
Category Explanation:  
Expected Number of Awards:  
CFDA Number(s): 93.313 — NIH Office of Research on Women’s Health
93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Aug 17, 2016
Last Updated Date: Aug 17, 2016
Original Closing Date for Applications: Oct 11, 2017  
Current Closing Date for Applications: Oct 11, 2017  
Archive Date: Nov 11, 2017
Estimated Total Program Funding:  
Award Ceiling: $499,999
Award Floor:  

Eligibility

Eligible Applicants: Small businesses
Public and State controlled institutions of higher education
Public housing authorities/Indian housing authorities
State governments
City or township governments
For profit organizations other than small businesses
Independent school districts
Native American tribal governments (Federally recognized)
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
Special district governments
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Native American tribal organizations (other than Federally recognized tribal governments)
County governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Additional Information

Agency Name: National Institutes of Health
Description: The purpose of this Funding Opportunity Announcement is to invite applications that investigate the mechanisms mediating the interactions between sleep and diabetes-related metabolism using deep metabolic phenotyping approaches in healthy human populations and those with metabolic and/or sleep disorders.
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-16-005.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV

If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

Kidney Precision Medicine Project Tissue Interrogation Sites (UG3/UH3)

RFA-DK-16-027
Kidney Precision Medicine Project Tissue Interrogation Sites (UG3/UH3)
Department of Health and Human Services
National Institutes of HealthDigital-Health-Infographic-08-636x412

Background

AKI and CKD impose a significant global health burden. Yet, no effective therapies currently exist for AKI, and only a few are available for CKD. Community feedback indicates that—despite significant effort from industry and academia—development of pharmacologic therapies for AKI and CKD has been hampered by non-predictive animal models, the inability to identify and prioritize human targets, the limited availability of human kidney biopsy tissue, and a poor understanding of AKI and CKD heterogeneity [Kidney Research National Dialogue 2014; AKI Outcomes Meeting 2015; Kidney Precision Medicine Meeting 2016]. Historically, AKI and CKD have been described as single, uniform diseases; however, growing consensus suggests that different disease pathways lead to different subgroups of AKI and CKD (AKIs and CKDs). Access to human kidney biopsy tissue is a critical first step to define disease heterogeneity and determine the precise molecular pathways that will facilitate identification of specific drug targets and ultimately enable individualized care for people with AKI and CKD.

Recent advances in multi-scale interrogation of human tissue and single cells have set the stage for precision medicine to be applied to AKI and CKD. The objectives of the KPMP are to ethically obtain and evaluate human kidney biopsies from participants with AKI or CKD, create a kidney tissue atlas, define disease subgroups, and identify critical cells, pathways and targets for novel therapies. The KPMP will be made up of three distinct, but highly interactive activities:

1.  Recruitment Sites: recruit people with AKI or CKD for longitudinal cohort studies that include a research kidney biopsy.

2.  Tissue Interrogation Sites: use and develop innovative technologies to analyze human kidney tissue (this FOA).

3.  Central Hub: aggregate, analyze and visualize all data and samples, and provide scientific, infrastructure and administrative support for the entire KPMP.

All data and samples from the RS and TIS will go to the CH. In addition to an Administrative Core (AC), the CH will have a Data and samples Coordinating Center (DCC) and a Data Visualization Center (DVC). The DCC will perform standard clinical data assessments (e.g., patient data reports, recruitment tables, observational study reports), whereas the DVC will perform digital pathological assessments and create a kidney tissue atlas (incorporating data and images generated by the RS and TIS) to help define disease subgroups and identify critical cells, pathways and targets for novel therapies. The DVC will also manage a KPMP website to facilitate the sharing of all de-identified data and samples with the broader research community.

While kidney tissue from transplant, nephrectomy, and autopsy will be used to optimize tissue interrogation methods, these do not provide the quality and diversity of tissue to meet all of the KPMP objectives. The KPMP requires research kidney biopsies (or clinical biopsies with research core(s); collectively called research kidney biopsies throughout this document) linked to longitudinal clinical phenotypic data and biosamples.

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-DK-16-027
Funding Opportunity Title: Kidney Precision Medicine Project Tissue Interrogation Sites (UG3/UH3)
Opportunity Category: Discretionary
Opportunity Category Explanation:  
Funding Instrument Type: Cooperative Agreement
Category of Funding Activity: Food and Nutrition
Health
Category Explanation:  
Expected Number of Awards:  
CFDA Number(s): 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Aug 17, 2016
Last Updated Date: Aug 17, 2016
Original Closing Date for Applications: Dec 06, 2016  
Current Closing Date for Applications: Dec 06, 2016  
Archive Date: Jan 06, 2017
Estimated Total Program Funding:  
Award Ceiling:  
Award Floor:

Eligibility

Eligible Applicants: Independent school districts
Public and State controlled institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
Native American tribal governments (Federally recognized)
Others (see text field entitled “Additional Information on Eligibility” for clarification)
City or township governments
Special district governments
For profit organizations other than small businesses
Public housing authorities/Indian housing authorities
Small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
County governments
State governments
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: This Funding Opportunity Announcement (FOA) requests applications for the  (KPMP) Tissue Interrogation Sites (TIS) to use and develop innovative technologies to analyze human kidney tissue. The TIS will collaborate with the KPMP Recruitment Sites and Central Hub to obtain and evaluate kidney biopsies from participants with acute kidney injury and chronic kidney disease, create a kidney tissue atlas, define disease subgroups, and identify critical cells, pathways and targets for novel therapies. Applicant teams should have documented experience with a current state-of-the-art method that can be used or adapted to interrogate human kidney tissue. The initial UG3 exploratory phase will be used to demonstrate that the site can interrogate existing tissue samples and small numbers of new biopsies. The UG3 phase will also encourage the development of next generation tissue interrogation technologies that probe the structural, functional and molecular complexities of kidney tissue. UG3 projects that have met their milestones will be administratively considered by the NIDDK and prioritized for transition to the UH3 implementation phase. UH3 awards will support further validation, scale-up and technology development. Applicants must address both the UG3 and UH3 phases. This FOA is intended to support only human studies and applications that include animal or model systems are not responsive.
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-16-027.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

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