Small Research Grants for Establishing Basic Science-Clinical Collaborations to Understand Structural Birth Defects (R03)

Small Research Grants for Establishing Basic Science-Clinical Collaborations to Understand Structural Birth Defects (R03)
Department of Health and Human Services
National Institutes of Health



The intent of this FOA is to support basic scientists, physician scientists (including individuals with DVM/VMD degrees), and/or clinicians in a collaborative effort to develop a multi-pronged research program focused on the etiology of a structural birth defect.  The R03 funding will specifically support formulation of the overall collaborative experimental approaches as well as the collection of preliminary data to support a future, larger grant application such as an R01.

The first aspect of developing an interdisciplinary collaboration is often time spent breaking down barriers between differing disciplines and establishing effective lines of communication.  For example, it is anticipated that pediatricians might need to learn more about developmental biology and genomics while developmental biologists might need to learn more about human genetics or epidemiology.  Therefore, part of the R03 should be devoted to the cross-disciplinary discussions necessary to build the foundation for the experimental approaches to tackle the problem at hand.

Depending on the combination of experimental approaches to be undertaken, the areas of expertise required are expected to vary.  For birth defects research to succeed in the long run, it is clear that interdisciplinary teams including but not limited to the following are necessary:  developmental biologists, cell biologists, geneticists, genomicists, clinicians, veterinarians with animal modeling and comparative medicine expertise, epidemiologists, biostatisticians, and/or bioinformaticists.  Therefore, the collaborative R03 should minimally include at least two PD/PIs with differing expertise.  Expertise from both the basic science side of the spectrum as well as the clinical side should be engaged in the R03 research.  The multiple PD/PI model is strongly encouraged but not required.

The scope of the research proposed is expected to vary as well.  The proposed studies should develop, adapt, and use approaches to identify genetic contributions as well as environmental interactions and other non-genetic determinants that contribute to various structural birth defects.  It is clear that genetic factors can be the primary cause of structural birth defects and/or may act in concert with environmental exposures.  Genetic and epigenetic factors provide a basis for functional studies in animal models or cell culture systems such as patient-derived induced pluripotent stem cells.  Introducing genetic variants into animal model systems can bolster the causative role of the variant as well as provide insight into the embryological mechanisms underlying structural birth defects.  Depending on the birth defect in question, the most appropriate model(s) will vary.  Examples of research areas that are appropriate for this FOA are described below.  This is not intended to be all-inclusive, but is designed merely to provide guidance and direction for applicants.

General Information

Document Type: Grants Notice
Funding Opportunity Number: PAR-16-323
Funding Opportunity Title: Small Research Grants for Establishing Basic Science-Clinical Collaborations to Understand Structural Birth Defects (R03)
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Grant
Category of Funding Activity: Education
Income Security and Social Services
Category Explanation:
Expected Number of Awards:
CFDA Number(s): 93.113 — Environmental Health
93.121 — Oral Diseases and Disorders Research
93.273 — Alcohol Research Programs
93.279 — Drug Abuse and Addiction Research Programs
93.351 — Research Infrastructure Programs
93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders
93.865 — Child Health and Human Development Extramural Research
Cost Sharing or Matching Requirement: No
Posted Date: Jun 10, 2016
Last Updated Date: Jun 10, 2016
Original Closing Date for Applications: Sep 07, 2019  
Current Closing Date for Applications: Sep 07, 2019  
Archive Date: Oct 08, 2019
Estimated Total Program Funding:
Award Ceiling: $75,000


Eligible Applicants:
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Private institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Public housing authorities/Indian housing authorities
County governments
State governments
Public and State controlled institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Independent school districts
Small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
Special district governments
Native American tribal governments (Federally recognized)
For profit organizations other than small businesses
City or township governments
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: The purpose of this funding opportunity announcement (FOA) is to promote initial establishment of basic science-clinical collaborations by providing small grants to teams of basic scientists, physician scientists, and/or clinicians. These interdisciplinary teams may include but are not limited to the following: developmental biologists, cell biologists, geneticists, genomicists, physician scientists including individuals with DVM/VMD degrees, clinicians, epidemiologists, biostatisticians, and/or bioinformaticists.
Link to Additional Information:
Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV
If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster


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