Program to Assess the Rigor and Reproducibility of Exosome-Derived Analytes for Cancer Detection (R01)

PAR-16-276
Program to Assess the Rigor and Reproducibility of Exosome-Derived Analytes for Cancer Detection (R01)
Department of Health and Human Services
National Institutes of Health

Background

Exosome-Derived Analytes Mirror Cancer Cells: The trafficking of biological analytes (e.g., proteins, metabolites, nucleotides) across the cell membrane is part of any normal cell homeostasis. In a vesicular transport mechanism, the analytes are transported across the cell membrane via exosomes, which are small extracellular vesicles. In pathological states such as cancer, the circulating exosome-derived analytes may mirror the altered state (e.g., over- or under expressed key proteins and microRNAs) of the cell of origin, and therefore, can be of substantial diagnostic value. Over the past decade, a number of studies have implicated exosomes in major tumor-related pathways such as hypoxia-driven epithelial-to-mesenchymal transition, cancer stemness, angiogenesis, malignant formation, metastasis and drug resistance However, the findings have been inconsistent and variable.

exosomes-lecture-9-638

 

 

 

 

 

 

 

 

Exosome are and other extracellular vesicles (EVs) are membrane enclosed vesicles that are secreted by all cells, circulated in the blood and are readily accessible in most body fluids. The cargo of these vesicles includes RNA, DNA, proteins, metabolites and lipids that are reflective of the cell of origin making exosomes appealing for biomarker development. EVs are categorized into exosomes, microvesicles, apoptotic bodies and Golgi vesicles. Exosomes are formed when multivesicular endosomes (MVE) fuse to the plasma membrane. Once secreted into the extracellular environment exosomes can function as mediators of intercellular signaling, can modulate the stroma and endothelial tissue, and can regulate inflammatory and immune responses. Cancer cells release more exosomes than normal cells and exosomes secreted from tumor cells can promote tumor progression, survival, invasion and angiogenesis. The analysis of exosomes isolated from blood or other body fluids could provide insight on cancer cell biology and predictive biomarkers for early detection, progression and metastasis.

General Information

Document Type: Grants Notice
Funding Opportunity Number: PAR-16-276
Funding Opportunity Title: Program to Assess the Rigor and Reproducibility of Exosome-Derived Analytes for Cancer Detection (R01)
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Grant
Category of Funding Activity: Education
Health
Category Explanation:
Expected Number of Awards:
CFDA Number(s): 93.394 — Cancer Detection and Diagnosis Research
Cost Sharing or Matching Requirement: No
Posted Date: May 23, 2016
Last Updated Date: May 23, 2016
Original Closing Date for Applications: Jun 13, 2019  
Current Closing Date for Applications: Jun 13, 2019  
Archive Date: Jul 14, 2019
Estimated Total Program Funding:
Award Ceiling:
Award Floor:

Eligibility

Eligible Applicants:
Special district governments
Public and State controlled institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Public housing authorities/Indian housing authorities
Native American tribal organizations (other than Federally recognized tribal governments)
Private institutions of higher education
Small businesses
County governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
State governments
Native American tribal governments (Federally recognized)
Independent school districts
Others (see text field entitled “Additional Information on Eligibility” for clarification)
For profit organizations other than small businesses
City or township governments
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: This Funding Opportunity Announcement (FOA) encourages research projects that focus on innovative research in the isolation and characterization of exosomes and their cargo for discovery of predictive biomarkers for risk assessment, detection, diagnosis and prognosis of early cancer. This FOA will promote rigor and reproducibility research in both the isolation of exosomes as well as the computational analysis of the cargo carried in these vesicles.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PAR-16-276.html
Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV
If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

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