Mechanisms of Cancer and Treatment-related Symptoms and Toxicities (R21)

PA-16-258
Mechanisms of Cancer and Treatment-related Symptoms and Toxicities (R21)
Department of Health and Human Services
National Institutes of Healthbladder-cancer-s1-illustration-of-bladder-cancer

Purpose

This FOA is intended to stimulate research aimed at better understanding the complex interaction of biological, cognitive, behavioral, and sociocultural factors that contribute to cancer and treatment related symptoms and toxicities throughout the disease trajectory. Data from these preliminary studies would be used to validate and extend the findings in larger cohort studies and/or test novel, mechanistically-driven interventions via the R01 funding mechanism. Of particular interest is to gain new insights about these factors, either alone or in combination, in minority, underserved, the elderly, and pediatric and young adult populations. Specifically, the FOA aims to identify, describe, and quantify these factors associated with acute and chronic symptoms and toxicities.

This FOA will utilize the exploratory/developmental research grant (R21) mechanism to foster cancer etiology and epidemiology research. While these studies may involve considerable risk, they may also lead to a breakthrough in a particular area, and to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of cancer research (epidemiologic, biomedical, behavioral, or clinical).

Specific Research Objectives

Applications submitted to this FOA should examine the complex interaction of biological, cognitive, behavioral, and sociocultural factors that contribute to cancer and treatment related symptoms and toxicities throughout the disease trajectory. Applications should bring together transdisciplinary teams of investigators with expertise in symptom science, including behavior, biology, and other basic and clinical science disciplines relevant to the pathways being studied. The research may occur in a variety settings (academic, community), during the various stages of the disease trajectory (diagnosis, active treatment, post-treatment/survivorship, palliative care, hospice).

Research areas may include, but not limited to:

Biologic mechanisms of symptoms and toxicities

1. What biomarkers are ready to be validated in the clinical setting to elucidate the mechanisms of symptoms and treatment related toxicities?

2. What are the biomarkers that determine individual susceptibilities to symptoms and toxicities, either alone or in combination?

3. How do certain co-morbidities affect the development and severity of symptoms and toxicities?

4. What is the natural trajectory of selected symptoms lacking information?

5 Are there biological differences by race that would impart a different symptom experience?

Behavioral, psychological, and sociocultural factors contributing to the development of symptoms and toxicities

1. How do factors such as gender, age, and race/ethnicity influence the development and severity of symptoms and toxicities?

2. What are the clinical, genetic and behavioral profiles of patients, including racially and ethnically diverse populations, undergoing the same cancer treatment, who do and do not develop disease and treatment related symptoms and toxicities.

3. Are there predictive models of who may or may not develop certain symptoms and toxicities? Can severity and duration (acute to chronic) be predicted?

4. What are the influences of knowledge, attitudes and culture on the experience of symptoms and toxicities?

5. What factors, including self-management strategies, influence reporting of symptoms and toxicities?

Patient reported outcomes (PROs) in symptom research

1. What novel methods for the analysis of PROs, symptom and toxicity data can be developed beyond descriptive?

2. How can PRO data be used to customize interventions to prevent or manage symptoms and toxicities?

3. What PRO tools need validation in special populations or cultures?

The following types of projects are not appropriate for this FOA:

Clinical trials, either randomized or single arm, aimed at preventing or treating cancer or treatment related symptoms and toxicities.

General Information

Document Type: Grants Notice
Funding Opportunity Number: PA-16-258
Funding Opportunity Title: Mechanisms of Cancer and Treatment-related Symptoms and Toxicities (R21)
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Grant
Category of Funding Activity: Education
Health
Category Explanation:
Expected Number of Awards:
CFDA Number(s): 93.393 — Cancer Cause and Prevention Research
Cost Sharing or Matching Requirement: No
Posted Date: May 16, 2016
Last Updated Date: May 16, 2016
Original Closing Date for Applications: Sep 07, 2019  
Current Closing Date for Applications: Sep 07, 2019  
Archive Date: Oct 08, 2019
Estimated Total Program Funding:
Award Ceiling: $200,000

Eligibility

Eligible Applicants:
Independent school districts
State governments
Public housing authorities/Indian housing authorities
For profit organizations other than small businesses
City or township governments
Native American tribal governments (Federally recognized)
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Small businesses
Special district governments
Native American tribal organizations (other than Federally recognized tribal governments)
Private institutions of higher education
Public and State controlled institutions of higher education
County governments
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: This Funding Opportunity Announcement (FOA) invites innovative pilot projects or feasibility studies to stimulate research aimed to better understand the complex interaction of biological, cognitive, behavioral, and sociocultural factors that contribute to cancer and treatment related symptoms and toxicities throughout the cancer care trajectory. Data from the preliminary studies would be used to validate and extend the findings in larger cohort studies and/or test novel, mechanistically-driven interventions via the R01 funding mechanism. Of particular interest is to gain new insights about these factors, either alone or in combination, in minority, underserved, the elderly, and pediatric and young adult populations. Specifically, the FOA aims to identify, describe, and quantify these factors associated with acute and chronic cancer and treatment related symptoms and toxicities.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PA-16-258.html
Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV
If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

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