Genome Sequencing Center for the Gabriella Miller Kids First Pediatric Research Program (U24)

RFA-RM-16-001
Genome Sequencing Center for the Gabriella Miller Kids First Pediatric Research Program (U24)
Department of Health and Human Services
National Institutes of Health

Gabriella-Miller21

Introduction

In response to The Gabriella Miller Kids First Act (https://www.govtrack.us/congress/bills/113/hr2019/text), NIH, through the Common Fund, has established the Gabriella Miller Kids First Pediatric Research Program (Kids First Program).  This program is intended to support a ten-year effort to develop an integrated Gabriela Miller Kids First Pediatric Data Resource (Kids First Data Resource) populated by genomic and phenotypic data that will be of high value for the pediatric research community.  This resource will allow data mining across diverse conditions to uncover shared developmental pathways.  The overall goal is to help researchers understand the underlying mechanisms of disease, leading to more refined diagnostic capabilities and ultimately more targeted therapies or interventions.

As the first step toward building the Kids First Data Resource, the Kids First Program published the Funding Opportunity Announcement, PAR-15-259, “Discovery of the Genetic Basis of Structural Birth Defects and of Childhood Cancers: Gabriella Miller Kids First Pediatric Research Program (X01)”, to solicit project/sample proposals to use whole genome sequencing to investigate the genetics of structural birth defects and the genetic contributions to childhood cancers.  Future calls will be published to continue the solicitation of similar types of projects and samples, pending availability of funds.

This FOA invites applications for sequencing center(s) that will produce whole genome sequence and variant data from the solicited samples (X01 samples) to contribute to the Kids First Data Resource.  It is funded through the NIH Common Fund, which supports cross-cutting programs that are expected to have exceptionally high impact. All Common Fund initiatives invite investigators to develop bold, innovative, and often risky approaches to address problems that may seem intractable or to seize new opportunities that offer the potential for rapid progress.

Goals

The goals of this FOA are as follows:

  • Generation of whole genome sequence data and variant data from cohorts for structural birth defects and childhood cancers that the Kids First Program will provide.
  • Submission of sequence and variant data to the controlled public database of Genotypes and Phenotypes (dbGaP), and databases that may be designated by the Kids First Program, and providing the same data to the project/sample Program Directors/Principal Investigators (PDs/PIs) (X01 PDs/PIs).
  • Coordination with X01PDs/PIs who will submit the phenotypic data of the sequenced samples to the same databases.

The FOA expects high quality sequence and variant data to be generated from the largest number of cases and samples possible with available funds.  It is anticipated that costs will decrease over the course of the award while data quality is maintained or improved, so the number of cases that can be sequenced and analyzed per dollar spent is expected to increase.

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-RM-16-001
Funding Opportunity Title: Genome Sequencing Center for the Gabriella Miller Kids First Pediatric Research Program (U24)
Opportunity Category: Discretionary
Funding Instrument Type: Cooperative Agreement
Category of Funding Activity: Health
Category Explanation:
Expected Number of Awards:
CFDA Number(s): 93.310 — Trans-NIH Research Support
Cost Sharing or Matching Requirement: No
Posted Date: Jan 13, 2016
Creation Date: Jan 13, 2016
Original Closing Date for Applications: Mar 31, 2016  
Current Closing Date for Applications: Mar 31, 2016  
Archive Date: May 1, 2016
Estimated Total Program Funding: $12,600,000
Award Ceiling: $12,600,000
Award Floor:

Eligibility

Eligible Applicants:
City or township governments
County governments
For profit organizations other than small businesses
Private institutions of higher education
State governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Special district governments
Native American tribal governments (Federally recognized)
Public and State controlled institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Additional Information on Eligibility: See full announcement for complete details.

Additional Information

Agency Name: National Institutes of Health
Description: The purpose of this Funding Opportunity Announcement (FOA) is to establish one or two centers that can rapidly generate high quality whole genome sequence and variant data from a large number of human specimens representing two types of pediatric conditions – structural birth defects and childhood cancers. The generated data will become a part of a data resource under The Gabriella Miller Kids First Pediatric Research Program, which will allow researchers to investigate the genetic etiology of structural birth defects, and to further elucidate the genetic contribution to childhood cancers.
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-16-001.html
Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

eRA Service Desk Monday to Friday 7 am to 8 pm ET http://grants.nih.gov/support/ Phone 1-866-504-9552
Grants Info

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