Limited Competition for the Continuation of the Scientific Data Research Center (SDRC) for the NIDDK Gastroparesis Consortium (U24)

RFA-DK-16-507
Limited Competition for the Continuation of the Scientific Data Research Center (SDRC) for the NIDDK Gastroparesis Consortium (U24)
Department of Health and Human Services
National Institutes of Health

Background

Gastroparesis is a chronic symptomatic disorder associated with delayed gastric emptying.

Gastroparesis predominantly affects young women (females outnumber males by a ratio of 4:1, the average age is 34). The symptomatic profile of gastroparesis includes nausea (90% of patients), vomiting (>80%), bloating (75%), early satiety (60%), and abdominal pain (~50%). Symptoms in individual patients can vary in both the combination of symptoms and their severity. Because of its chronic and often intractable nature, the disorder has a tremendous impact on both patients and society. Gastroparesis remains difficult to treat, in large part, because of the lack of knowledge of the underlying pathophysiology. Several factors have impeded the progress in this field including the paucity of patients seen by any one center, the absence of uniform diagnostic criteria, and the lack of generally available and reliable methods for physiological testing. Given the complexity of the problem, and the profound degree of morbidity associated with this disorder, an important need exists to study patients in a systematic manner. Such studies can best be achieved by recruiting patients and collecting data from multiple centers as part of a network of investigators focused on this disorder. In recognition of this fact, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) established the Gastroparesis Clinical Research Consortium (GpCRC) in 2006 and renewed the consortium in 2010. Since many gaps still existed despite the progress of the consortium, in April 2015, an External Scientific Committee recommended support of the Consortium activities for another 5 years.

Research Objectives
Through the acquisition of a cohort of well-characterized patients and associated biospecimens (blood, stools and when feasible gastric  tissue), the clinical research consortium  will provide the resources and collaborative opportunities necessary for achieving many of the research objectives identified in the strategic plan of NIDDK for Gastroparesis.

The overriding objective of this research program is to pursue clinical research on Gastroparesis  (both sporadic and  associated with diabetes mellitus type 1 and 2 and obesity), by identifying and characterizing a large cohort of patients with gastroparesis to encourage translational research focusing upon elucidating the pathogenesis that will provide the basis for understanding the natural history and developing means of diagnosis, treatment and clinical management of Gastroparesis  and its sequela: chronic abdominal pain, nausea, vomiting, poor metabolic control and impaired quality of life.

General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-DK-16-507
Funding Opportunity Title: Limited Competition for the Continuation of the Scientific Data Research Center (SDRC) for the NIDDK Gastroparesis Consortium (U24)
Opportunity Category: Discretionary
Funding Instrument Type: Cooperative Agreement
Category of Funding Activity: Food and Nutrition
Health
Category Explanation:
Expected Number of Awards: 1
CFDA Number(s): 93.847 — Diabetes, Digestive, and Kidney Diseases Extramural Research
Cost Sharing or Matching Requirement: No
Posted Date: Dec 22, 2015
Creation Date: Dec 22, 2015
Original Closing Date for Applications: Mar 2, 2016  
Current Closing Date for Applications: Mar 2, 2016  
Archive Date: Apr 2, 2016
Estimated Total Program Funding: $4,300,000
Award Ceiling: $1,000,000
Award Floor:

Eligibility

Eligible Applicants:
Private institutions of higher education
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Public and State controlled institutions of higher education
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Additional Information

Agency Name: National Institutes of Health
Description: This Funding Opportunity Announcement (FOA) invites an application for the Scientific Data Research Center (SDRC) of the Gastroparesis Clinical Research Consortium (GpCRC). The purpose of this FOA is to allow additional follow-up of GpCRC participants. The companion FOA, RFA-DK-16-010 will support continuation of the GpCRC Clinical Centers (CC).
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-16-507.html
Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV
If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s