PAR-15-085 “Predictive Multiscale Models for Biomedical, Biological, Behavioral, Environmental and Clinical Research (U01)”

Notice of National Center for Complementary and Integrative Health (NCCIH) Participation in PAR-15-085 “Predictive Multiscale Models for Biomedical, Biological, Behavioral, Environmental and Clinical Research (U01)”


Notice Number: NOT-AT-15-009

Key Dates
Release Date:  July 2, 2015

Related Announcements
PAR-15-085

Issued by
National Center for Complementary and Integrative Health (NCCIH)

Purpose

The purpose of this Notice is to inform potential applicants that the National Center for Complementary and Integrative Health (NCCIH) is participating, effective immediately, in PAR-15-085 “Predictive Multiscale Models for Biomedical, Biological, Behavioral, Environmental and Clinical Research (U01).”

The following sections of PAR-15-085 have been updated to reflect NCCIH’s participation in this funding opportunity announcement.

Part 1. Overview Information

Components of Participating Organizations
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
National Cancer Institute (NCI)
National Human Genome Research Institute (NHGRI)
National Institute on Aging (NIA)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
National Institute on Drug Abuse (NIDA)
National Institute of Environmental Health Sciences (NIEHS)
Office of Behavioral and Social Sciences Research (OBSSR)
The U.S. Army Research Office (ARO) – Biomathematics
Department of Energy (DOE) – Office of Science, Biological and Environmental Research Program (BER)
U.S. Food and Drug Administration (FDA) – Office of In-Vitro Diagnostics and Radiological Health (OIR), CDRH
U.S. Food and Drug Administration (FDA) – Office of Device Evaluation (ODE), CDRH
U.S. Food and Drug Administration (FDA) – Office of Science and Engineering Laboratories (OSEL), CDRH
National Science Foundation (NSF) – Directorate for Computer & Information Science & Engineering (CISE)
National Science Foundation (NSF) – Directorate for Engineering (ENG)
National Science Foundation (NSF) – Directorate for Mathematical and Physical Sciences (MPS)
The National Aeronautics and Space Administration (NASA) – Human Research Program (HRP)
The Office of Naval Research (ONR) – Division 311
National Heart, Lung, and Blood Institute (NHLBI)
National Center for Complementary and Integrative Health (NCCIH)

Catalog of Federal Domestic Assistance (CFDA) Numbers
93.286, 93.172, 93.866, 93.279, 93.859, 93.865, 93.273, 93.396, 47.049, 47.041, 47.080, 43.003, 93.846, 93.103, 81.049, 12.300, 12.431, 93.837, 93.838, 93.839, 93.233, 93.213

Part 2. Section I. Funding Opportunity Description

Specific interests:
The National Center for Complementary and Integrative Health (NCCIH) is interested in supporting the development of innovative predictive models related to the mechanisms of complementary and integrative approaches, including natural products and mind and body interventions, in human subjects or appropriate model systems.  Randomized clinical trials to validate the predictive models in humans are not supported by this FOA and should seek other funding mechanisms supported by the NCCIH.   Examples of research topics include but are not limited to:

  • Multiscale models related to predictive and/or modifiable mechanisms of natural products or mind and body approaches (i.e. spinal manipulation or mobilization, massage, tai chi, qi gong, yoga, acupuncture, hypnosis, meditation, biofeedback or mindfulness techniques) for pain management.
  • Multiscale models related to predictive and/or modifiable mechanisms of mind and body approaches (i.e. spinal manipulation or mobilization, massage, tai chi, qi gong, yoga, acupuncture, hypnosis, meditation, biofeedback or mindfulness techniques) for post-traumatic stress (disorder), sleep disorders or disturbances, anxiety, or depression.
  • Multi-scale modeling research for preventative strategies that links genetics, molecular mechanisms, intracellular signaling, brain circuits, and/or environment with responders and non-responders of complementary interventions (i.e. acupuncture, mindfulness, yoga, natural products, etc.) and/or integrative health interventions.
  • Models to predict the systems level biological activity of natural products, especially in the context of complex natural product mixtures as is common in traditional systems of medicine
  • Multi-scale models and computational approaches of mechanistic pathways and regulatory networks in probiotic/prebiotic and microbiota-brain-gut interactions and related bio-behavioral networks that can be used consistently in unifying multi-scale frameworks (e.g., neural-hormonal biological systems and microecological principles that promote homeostasis or disease)

Part 2. Section VII. Agency Contacts

Scientific/Research Contact(s)
Wen G. Chen, Ph.D.
National Center for Complementary and Integrative Health (NCCIH)
Telephone: 301-451-3989
Email: chenw@mail.nih.gov

Financial/Grants Management Contact(s)
Shelley Carow
National Center for Complementary and Integrative Health (NCCIH)
Telephone: 301-594-3788
Email: carows@mail.nih.gov

All other aspects of the FOA remain unchanged.

Inquiries

Please direct all inquiries to:

Wen G. Chen, Ph.D.
National Center for Complementary and Integrative Health (NCCIH)
Telephone: 301-451-3989
Email: chenw@mail.nih.gov

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