Notice of Intent to Publish a Funding Opportunity for a Clinical Trials Network for Emergency Care Research: Regional Clinical Centers (U24)

Notice Number: NOT-NS-15-021

Key Dates
Release Date:  May 5, 2015
Estimated Publication Date of Announcement: November 2015
First Estimated Application Due Date:  March 2016
Earliest Estimated Award Date:  December 2016
Earliest Estimated Start Date: December 2016

Related Announcements
NOT-NS-15-022
NOT-NS-15-023

Issued by
National Institute of Neurological Disorders and Stroke (NINDS)
National Heart, Lung, and Blood Institute (NHLBI)
National Center for Advancing Translational Sciences (NCATS)

Purpose

The National Institute of Neurologic Disorders and Stroke (NINDS), the National Heart, Lung and Blood Institute (NHLBI), the National Center for Advancing Translational Science (NCATS), the Office of Emergency Care Research (OECR) in the National Institute of General Medical Sciences (NIGMS), and the Defense Medical Research and Development Program for Combat Casualty Care (DMRDP) intend to publish a Funding Opportunity Announcement (FOA) to solicit applications for an emergency care clinical trials network entitled Strategies to Innovate EmeRgENcy Care Clinical Trials (SIREN).  The network will be composed of a Clinical Coordinating Center (CCC), a Data Coordinating Center (DCC), and multiple Regional Clinical Centers with their linked clinical sites. The network will be charged with executing trials of high impact for the treatment of patients with neurological, cardiac, pulmonary, hematologic and traumatic medical and surgical emergencies.  Applications for SIREN trials will be solicited from the national scientific community. Investigator-initiated clinical trials that are considered highly meritorious by peer-review will be funded separately for execution by the network, in some cases coordinated with additional trial-specific sites.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.

The FOA is expected to be published in November, 2015 with an expected application due date in March, 2016.

This FOA will utilize the U24 activity code.

Research Initiative Details

This Notice encourages investigators with expertise in emergency care research, particularly neurologic, heart, lung, blood and trauma related indications, to begin to consider applying for this new FOA.

The SIREN network will be responsible for simultaneously executing at least 4 large, randomized, clinical trials that focus on improving care of patients with emergency conditions relevant to the mission of NINDS, NHLBI and the Defense Medical Research and Development Program for Combat Casualty Care (DMRDP) presenting to the pre-hospital or emergency department setting.  The Regional Clinical Centers will work collaboratively with the SIREN Clinical and Data Coordinating Centers, including use of the central IRB and master trial agreements formed by the Clinical Coordinating Center in coordination with the new Trial Innovation Centers being set up by the National Center for Advancing Translational Science.  Regional Coordinating Centers are expected to establish and work with subsidiary clinical sites, the identity and number of which may vary from protocol to protocol. The SIREN Regional Clinical Centers will be responsible for patient recruitment and treatment for SIREN studies

APPLICATIONS ARE NOT BEING SOLICITED AT THIS TIME.

Inquiries

Please direct all inquiries to:

Robin Conwit, MD
National Institute Neurologic Disorders and Stroke (NINDS)
Telephone: 301-496-3299
Email: conwitr@ninds.nih.gov

Monica Shah, MD, FACC
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-435-0504
Email: shahmr@nhlbi.nih.gov

Jeremy Brown, MD
National Institute of General Medical Sciences (NIGMS)
Telephone: 301-594-4481
Email: jeremy.brown@nih.gov

– See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-NS-15-021.html#sthash.FDGAGySh.dpuf

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Notice of Intent to Publish a Funding Opportunity for a Clinical Trials Network for Emergency Care Research: Data Coordinating Center (U24)

Notice of Intent to Publish a Funding Opportunity for a Clinical Trials Network for Emergency Care Research: Data Coordinating Center (U24)


Notice Number: NOT-NS-15-023NHLBI_Standard_Sig_Logo_RGB

Key Dates
Release Date:   May 5, 2015
Estimated Publication Date of Announcement: November 2015
First Estimated Application Due Date:  March 2016
Earliest Estimated Award Date:  December 2016
Earliest Estimated Start Date: December 2016

Related Announcements
NOT-NS-15-022
NOT-NS-15-021

Issued by
National Institute of Neurological Disorders and Stroke (NINDS)
National Heart, Lung, and Blood Institute (NHLBI)
National Center for Advancing Translational Sciences (NCATS)

Purpose

The National Institute of Neurologic Disorders and Stroke (NINDS), the National Heart, Lung and Blood Institute (NHLBI), the National Center for Advancing Translational Science (NCATS), and the Defense Medical Research and Development Program for Combat Casualty Care (DMRDP), with expert consultation from the Office of Emergency Care Research (OECR), intend to publish a Funding Opportunity Announcement (FOA) to solicit applications for an emergency care clinical trials network entitled Strategies to Innovate EmeRgENcy Care Clinical Trials (SIREN).  The network will be composed of a Clinical Coordinating Center (CCC), a Data Coordinating Center (DCC), and multiple Regional Clinical Centers with their linked clinical sites. The network will be charged with executing trials of high impact for the treatment of patients with traumatic, neurologic, cardiac, pulmonary, hematologic and traumatic medical and surgical emergencies.  Proposals for SIREN trials will be solicited from the national scientific community. Investigator-initiated clinical trials that are considered highly meritorious by peer-review will be funded separately for execution by the network, in some cases coordinated with additional trial-specific sites.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.

There will be three FOAs for the emergency care network, one for the CCC, one for the DCC and one for the Regional Clinical Centers.   This FOA for the DCC is expected to be published in November, 2015 with an expected application due date in March, 2016.

This FOA will utilize the U24 activity code.

Research Initiative Details

This Notice encourages investigators with expertise in emergency care research, particularly neurologic, heart, lung, blood and trauma related indications, to begin to consider applying for this new FOA.

The SIREN network will be responsible for simultaneously executing at least 4 large, randomized, clinical trials that focus on improving care of patients with emergency conditions relevant to the mission of NINDS, NHLBI and the DMRDP presenting to the pre-hospital or emergency department setting.   The DCC will be responsible for all components of data management, data quality and data analysis, including provision of data to Data Safety Management Boards.  The SIREN DCC will work closely and collaboratively with the SIREN Clinical Coordinating Center.  The CCC and DCC will be located at different institutions.

APPLICATIONS ARE NOT BEING SOLICITED AT THIS TIME.

Inquiries

Please direct all inquiries to:

Robin Conwit, MD
National Institute of Neurological Disorders and Stroke (NINDS)
Telephone: 301-496-3299
Email: conwitr@ninds.nih.gov

Monica Shah, MD, FACC
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-435-0504
Email: shahmr@nhlbi.nih.gov

– See more at: http://grants.nih.gov/grants/guide/notice-files/NOT-NS-15-023.html#sthash.hm4O45sv.dpuf

Notice of Intent to Publish a Funding Opportunity for a Clinical Trials Network for Emergency Care Research: Clinical Coordinating Center (U24)

Notice of Intent to Publish a Funding Opportunity for a Clinical Trials Network for Emergency Care Research: Clinical Coordinating Center (U24)


Notice Number: NOT-NS-15-022ninds

Key Dates
Release Date:   May 5, 2015
Estimated Publication Date of Announcement: November 2015
First Estimated Application Due Date:  March 2016
Earliest Estimated Award Date: December 2016
Earliest Estimated Start Date: December 2016

Related Announcements
NOT-NS-15-021
NOT-NS-15-023

Issued by
National Institute of Neurological Disorders and Stroke (NINDS)
National Heart, Lung, and Blood Institute (NHLBI)
National Center for Advancing Translational Sciences (NCATS)

Purpose

The National Institute of Neurologic Disorders and Stroke (NINDS), the National Heart, Lung and Blood Institute (NHLBI), the National Center for Advancing Translational Science (NCATS) and the Defense Medical Research and Development Program for Combat Casualty Care (DMRDP), with expert consultation from the Office of Emergency Care Research (OECR), intend to publish a Funding Opportunity Announcement (FOA) to solicit applications for an emergency care clinical trials network entitled Strategies to Innovate EmeRgENcy Care Clinical Trials (SIREN).  The network will be composed of a Clinical Coordinating Center (CCC), a Data Coordinating Center (DCC), and multiple Regional Clinical Centers with their linked clinical sites. The network will be charged with executing trials of high impact for the treatment of patients with neurologic, cardiac, pulmonary, hematologic  and traumatic medical and surgical emergencies.  Proposals for SIREN trials will be solicited from the national scientific community. Investigator-initiated clinical trials that are considered highly meritorious by peer-review will be funded separately for execution by the network, in some cases coordinated with additional trial-specific sites.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.

The FOA is expected to be published in November, 2015 with an expected application due date in March, 2016.

This FOA will utilize the U24 activity code.

Research Initiative Details

This Notice encourages investigators with expertise in emergency care research, particularly neurological, heart, lung, blood and trauma related indications, to begin to consider applying for this new FOA.

The SIREN network will be responsible for simultaneously executing at least 4 large, randomized, clinical trials that focus on improving care of patients with emergency conditions relevant to the mission of NINDS, NHLBI and the Defense Medical Research and Development Program for Combat Casualty Care (DMRDP) presenting to the pre-hospital or emergency department setting.  The SIREN Clinical Coordinating Center, in coordination with the new Trial Innovation Centers being set up by the National Center for Advancing Translational Science, will form and manage a central IRB and master contract process for SIREN studies

APPLICATIONS ARE NOT BEING SOLICITED AT THIS TIME.

Inquiries

Please direct all inquiries to:

Robin Conwit, MD
National Institute Neurologic Disorders and Stroke (NINDS)
Telephone: 301-496-3299
Email: conwitr@ninds.nih.gov

Monica Shah, MD, FACC
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-435-0504
Email: shahmr@nhlbi.nih.gov

PAR-15-259
Discovery of the Genetic Basis of Structural Birth Defects and of Childhood Cancers: Gabriella Miller Kids First Pediatric Research Program (X01)
Department of Health and Human Services
National Institutes of Health

The synopsis for this grant opportunity is detailed below, following this paragraph. This synopsis contains all of the updates to this document that have been posted as of 5/15/2015. If updates have been made to the opportunity synopsis, update information is provided below the synopsis.

If you would like to receive notifications of changes to the grant opportunity click send me change notification emails. The only thing you need to provide for this service is your email address. No other information is requested.

Any inconsistency between the original printed document and the disk or electronic document shall be resolved by giving precedence to the printed document.
General Information

Document Type: Grants Notice
Funding Opportunity Number: PAR-15-259
Funding Opportunity Title: Discovery of the Genetic Basis of Structural Birth Defects and of Childhood Cancers: Gabriella Miller Kids First Pediatric Research Program (X01)
Opportunity Category: Discretionary
Funding Instrument Type: Grant
Category of Funding Activity: Health
Category Explanation:
Expected Number of Awards:
CFDA Number(s): 93.310 — Trans-NIH Research Support
Cost Sharing or Matching Requirement: No
Posted Date: May 15, 2015
Creation Date: May 15, 2015
Original Closing Date for Applications: Jul 27, 2015  
Current Closing Date for Applications: Jul 27, 2015  
Archive Date: Aug 27, 2015
Estimated Total Program Funding:
Award Ceiling:
Award Floor:

Eligibility

Eligible Applicants:
Others (see text field entitled “Additional Information on Eligibility” for clarification)
State governments
City or township governments
For profit organizations other than small businesses
Native American tribal organizations (other than Federally recognized tribal governments)
Special district governments
Public housing authorities/Indian housing authorities
Independent school districts
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Private institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Small businesses
Native American tribal governments (Federally recognized)
Public and State controlled institutions of higher education
County governments
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: The NIH invites applications to use whole genome sequencing at an NHGRI-supported sequencing center to investigate the genetic etiology of structural birth defects, and to further elucidate the genetic contribution to childhood cancers and the genomic contributions to treatment failure for childhood sarcomas.These data will become part of a data resource for the pediatric research community. Information from this activity will be used to help design future activities of the Gabriella Miller Kids First (Kids First) Pediatric Research Program.
Link to Additional Information: http://grants.nih.gov/grants/guide/pa-files/PAR-15-259.html
Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH OER Webmaster FBOWebmaster@OD.NIH.GOV
If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster

RFA-MD-15-012
Behavioral Interventions to Prevent HIV in Diverse Adolescent Men Who Have Sex with Men (U01)
Department of Health and Human Services
National Institutes of Health

The synopsis for this grant opportunity is detailed below, following this paragraph. This synopsis contains all of the updates to this document that have been posted as of 5/15/2015. If updates have been made to the opportunity synopsis, update information is provided below the synopsis.

If you would like to receive notifications of changes to the grant opportunity click send me change notification emails. The only thing you need to provide for this service is your email address. No other information is requested.

Any inconsistency between the original printed document and the disk or electronic document shall be resolved by giving precedence to the printed document.
General Information

Document Type: Grants Notice
Funding Opportunity Number: RFA-MD-15-012
Funding Opportunity Title: Behavioral Interventions to Prevent HIV in Diverse Adolescent Men Who Have Sex with Men (U01)
Opportunity Category: Discretionary
Funding Instrument Type: Cooperative Agreement
Category of Funding Activity: Health
Category Explanation:
Expected Number of Awards: 3
CFDA Number(s): 93.307 — Minority Health and Health Disparities Research
Cost Sharing or Matching Requirement: No
Posted Date: May 15, 2015
Creation Date: May 15, 2015
Original Closing Date for Applications: Jan 15, 2016  
Current Closing Date for Applications: Jan 15, 2016  
Archive Date: Feb 15, 2016
Estimated Total Program Funding: $6,000,000
Award Ceiling: $1,250,000
Award Floor:

Eligibility

Eligible Applicants:
Others (see text field entitled “Additional Information on Eligibility” for clarification)
For profit organizations other than small businesses
State governments
Independent school districts
Public and State controlled institutions of higher education
Public housing authorities/Indian housing authorities
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Native American tribal organizations (other than Federally recognized tribal governments)
Private institutions of higher education
Native American tribal governments (Federally recognized)
County governments
Small businesses
City or township governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Special district governments
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name: National Institutes of Health
Description: The purpose of this initiative is to test behavioral HIV prevention interventions for diverse populations of adolescent (age 13-18) men who have sex with men (MSM).
Link to Additional Information: http://grants.nih.gov/grants/guide/rfa-files/RFA-MD-15-012.html
Contact Information: If you have difficulty accessing the full announcement electronically, please contact:NIH OER Webmaster FBOWebmaster@OD.NIH.GOV
If you have any problems linking to this funding announcement, please contact the NIH OER Webmaster